From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4 , is a
protein that in humans is encoded by the TRPM4
gene .
[5]
[6]
TRPM4 Channel Blocker
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000130529 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000038260 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Xu XZ, Moebius F, Gill DL, Montell C (September 2001).
"Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform" . Proc. Natl. Acad. Sci. U.S.A . 98 (19): 10692–7.
doi :
10.1073/pnas.191360198 .
PMC
58528 .
PMID
11535825 .
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev . 57 (4): 427–50.
doi :
10.1124/pr.57.4.6 .
PMID
16382100 .
S2CID
17936350 .
Further reading
Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels . Advances in Experimental Medicine and Biology. Vol. 704. Berlin: Springer. p. 700.
ISBN
978-94-007-0264-6 .
Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP (2002).
"TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization" . Cell . 109 (3): 397–407.
doi :
10.1016/S0092-8674(02)00719-5 .
PMID
12015988 .
S2CID
14411824 .
Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP (2004). "TRPM4 regulates calcium oscillations after T cell activation". Science . 306 (5700): 1374–1377.
doi :
10.1126/science.1098845 .
PMID
15550671 .
S2CID
16459097 .
Vennekens R, Nilius B (2007). "Insights into TRPM4 function, regulation and physiological role". Transient Receptor Potential (TRP) Channels . Handbook of Experimental Pharmacology. Vol. 179. pp. 269–85.
doi :
10.1007/978-3-540-34891-7_16 .
ISBN
978-3-540-34889-4 .
PMID
17217063 .
Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M (2007).
"Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4" (PDF) . Nat Immunol . 8 (3): 312–320.
doi :
10.1038/ni1441 .
PMID
17293867 .
S2CID
29303898 .
Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P (2008).
"The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells" . Nat Immunol . 9 (10): 1148–56.
doi :
10.1038/ni.1648 .
PMC
2956271 .
PMID
18758465 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
TRPA
Activators
4-Hydroxynonenal
4-Oxo-2-nonenal
4,5-EET
12S-HpETE
15-Deoxy-Δ12,14 -prostaglandin J2
α-Sanshool (
ginger ,
Sichuan and
melegueta peppers )
Acrolein
Allicin (
garlic )
Allyl isothiocyanate (
mustard ,
radish ,
horseradish ,
wasabi )
AM404
ASP-7663
Bradykinin
Cannabichromene (
cannabis )
Cannabidiol (
cannabis )
Cannabigerol (
cannabis )
Cinnamaldehyde (
cinnamon )
CR gas (dibenzoxazepine; DBO)
CS gas (2-chlorobenzal malononitrile)
Cuminaldehyde (
cumin )
Curcumin (
turmeric )
Dehydroligustilide (
celery )
Diallyl disulfide
Dicentrine (
Lindera spp.)
Farnesyl thiosalicylic acid
Formalin
Gingerols (
ginger )
Hepoxilin A3
Hepoxilin B3
Hydrogen peroxide
Icilin
Isothiocyanate
JT-010
Ligustilide (
celery ,
Angelica acutiloba )
Linalool (
Sichuan pepper ,
thyme )
Methylglyoxal
Methyl salicylate (
wintergreen )
N-Methylmaleimide
Nicotine (
tobacco )
Oleocanthal (
olive oil )
Paclitaxel (
Pacific yew )
Paracetamol (acetaminophen)
PF-4840154
Phenacyl chloride
Polygodial (
Dorrigo pepper )
Shogaols (
ginger ,
Sichuan and
melegueta peppers )
Tear gases
Tetrahydrocannabinol (
cannabis )
Tetrahydrocannabiorcol
Thiopropanal S-oxide (
onion )
Umbellulone (Umbellularia californica )
WIN 55,212-2
Blockers
TRPC
TRPM
TRPML
TRPP
TRPV
Activators
2-APB
5',6'-EET
9-HODE
9-oxoODE
12S-HETE
12S-HpETE
13-HODE
13-oxoODE
20-HETE
α-Sanshool (
ginger ,
Sichuan and
melegueta peppers )
Allicin (
garlic )
AM404
Anandamide
Bisandrographolide (
Andrographis paniculata )
Camphor (
camphor laurel ,
rosemary ,
camphorweed ,
African blue basil ,
camphor basil )
Cannabidiol (
cannabis )
Cannabidivarin (
cannabis )
Capsaicin (
chili pepper )
Carvacrol (
oregano ,
thyme ,
pepperwort ,
wild bergamot , others)
DHEA
Diacyl glycerol
Dihydrocapsaicin (
chili pepper )
Estradiol
Eugenol (
basil ,
clove )
Evodiamine (
Euodia ruticarpa )
Gingerols (
ginger )
GSK1016790A
Heat
Hepoxilin A3
Hepoxilin B3
Homocapsaicin (
chili pepper )
Homodihydrocapsaicin (
chili pepper )
Incensole (
incense )
Lysophosphatidic acid
Low
pH (acidic conditions)
Menthol (
mint )
N-Arachidonoyl dopamine
N-Oleoyldopamine
N-Oleoylethanolamide
Nonivamide (PAVA) (
PAVA spray )
Nordihydrocapsaicin (
chili pepper )
Paclitaxel (
Pacific yew )
Paracetamol (acetaminophen)
Phenylacetylrinvanil
Phorbol esters (e.g.,
4α-PDD )
Piperine (
black pepper ,
long pepper )
Polygodial (
Dorrigo pepper )
Probenecid
Protons
RhTx
Rutamarin (
Ruta graveolens )
Resiniferatoxin (RTX) (
Euphorbia resinifera /
pooissonii )
Shogaols (
ginger ,
Sichuan and
melegueta peppers )
Tetrahydrocannabivarin (
cannabis )
Thymol (
thyme ,
oregano )
Tinyatoxin (
Euphorbia resinifera /
pooissonii )
Tramadol
Vanillin (
vanilla )
Zucapsaicin
Blockers