From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Acid-sensing ion channel 3 (ASIC3 ) also known as amiloride-sensitive cation channel 3 (ACCN3 ) or testis sodium channel 1 (TNaC1 ) is a
protein that in humans is encoded by the ASIC3
gene . The ASIC3 gene is one of the five
paralogous genes that encode proteins that form trimeric
acid-sensing ion channels (ASICs) in mammals.
[5] The cDNA of this gene was first cloned in 1998.
[6]
[7] The ASIC genes have splicing variants that encode different proteins that are called isoforms.
These genes are mainly expressed in the central and peripheral nervous system.
ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.
[8]
Structure and function
This gene encodes a member of the ASIC/
ENaC superfamily of proteins.
[9] The members of this family are
amiloride -sensitive
sodium channels that contain
intracellular N and C termini, 2
hydrophobic
transmembrane (TM) regions, and a large
extracellular loop, which has many
cysteine residues with conserved spacing. The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus).
The pore of the channel through which ions selectively flow from the extracellular side into the cytoplasm is formed by the three TM2 regions of the trimer.
[5]
Interactions
ASIC3 has been shown to
interact with
LIN7B ,
[10]
GOPC
[10] and
MAGI1 .
[10]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000213199 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000038276 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Hanukoglu I (2017).
"ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters" . FEBS Journal . 284 (4): 525–545.
doi :
10.1111/febs.13840 .
PMID
27580245 .
S2CID
24402104 .
^ Ishibashi K, Marumo F (June 1998). "Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis". Biochem. Biophys. Res. Commun . 245 (2): 589–93.
doi :
10.1006/bbrc.1998.8483 .
PMID
9571199 .
^ de Weille JR, Bassilana F, Lazdunski M, Waldmann R (October 1998).
"Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel" . FEBS Lett . 433 (3): 257–60.
Bibcode :
1998FEBSL.433..257D .
doi :
10.1016/S0014-5793(98)00916-8 .
PMID
9744806 .
S2CID
24431941 .
^ Babinski K, Catarsi S, Biagini G, Séguéla P (Sep 2000).
"Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+" . The Journal of Biological Chemistry . 275 (37): 28519–25.
doi :
10.1074/jbc.M004114200 .
hdl :
11380/304669 .
PMID
10842183 .
^ Hanukoglu I, Hanukoglu A (Jan 2016).
"Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases" . Gene . 579 (2): 95–132.
doi :
10.1016/j.gene.2015.12.061 .
PMC
4756657 .
PMID
26772908 .
^
a
b
c Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (November 2004).
"PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current" . J. Biol. Chem . 279 (45): 46962–8.
doi :
10.1074/jbc.M405874200 .
PMID
15317815 .
External links
Further reading
Babinski K, Lê KT, Séguéla P (1999).
"Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties" . J. Neurochem . 72 (1): 51–7.
doi :
10.1046/j.1471-4159.1999.0720051.x .
PMID
9886053 .
S2CID
10506798 .
Catarsi S, Babinski K, Séguéla P (2001). "Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF". Neuropharmacology . 41 (5): 592–600.
doi :
10.1016/S0028-3908(01)00107-1 .
PMID
11587714 .
S2CID
568441 .
Alvarez de la Rosa D, Zhang P, Shao D, White F, Canessa CM (2002).
"Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system" . Proc. Natl. Acad. Sci. U.S.A . 99 (4): 2326–31.
Bibcode :
2002PNAS...99.2326A .
doi :
10.1073/pnas.042688199 .
PMC
122364 .
PMID
11842212 .
Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E (2002).
"The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons" . J. Biol. Chem . 277 (19): 16655–61.
doi :
10.1074/jbc.M201087200 .
PMID
11872753 .
Chen CC, Zimmer A, Sun WH, Hall J, Brownstein MJ, Zimmer A (2002).
"A role for ASIC3 in the modulation of high-intensity pain stimuli" . Proc. Natl. Acad. Sci. U.S.A . 99 (13): 8992–7.
Bibcode :
2002PNAS...99.8992C .
doi :
10.1073/pnas.122245999 .
PMC
124411 .
PMID
12060708 .
Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ (2003).
"cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1" . Proc. Natl. Acad. Sci. U.S.A . 100 (4): 2029–34.
Bibcode :
2003PNAS..100.2029L .
doi :
10.1073/pnas.252782799 .
PMC
149953 .
PMID
12578970 .
Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (2004).
"PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current" . J. Biol. Chem . 279 (45): 46962–8.
doi :
10.1074/jbc.M405874200 .
PMID
15317815 .
Price MP, Thompson RJ, Eshcol JO, Wemmie JA, Benson CJ (2004).
"Stomatin modulates gating of acid-sensing ion channels" . J. Biol. Chem . 279 (51): 53886–91.
doi :
10.1074/jbc.M407708200 .
PMID
15471860 .
Jones NG, Slater R, Cadiou H, McNaughton P, McMahon SB (2004).
"Acid-induced pain and its modulation in humans" . J. Neurosci . 24 (48): 10974–9.
doi :
10.1523/JNEUROSCI.2619-04.2004 .
PMC
6730214 .
PMID
15574747 .
Su X, Li Q, Shrestha K, Cormet-Boyaka E, Chen L, Smith PR, Sorscher EJ, Benos DJ, Matalon S, Ji HL (2006).
"Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator" . J. Biol. Chem . 281 (48): 36960–8.
doi :
10.1074/jbc.M608002200 .
PMID
17012229 .