From Wikipedia, the free encyclopedia
Protein and coding gene in humans
Transient receptor potential canonical 1 (TRPC1 ) is a
protein that in humans is encoded by the TRPC1
gene .
[5]
[6]
Function
TRPC1 is an
ion channel located on the plasma membrane of numerous human and animal cell types.
[7]
It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the
phospholipase C system. In HEK293 cells the unitary current-voltage relationship of
endogenous TRPC1 channels is almost linear, with a slope conductance of about 17 pS. The extrapolated reversal potential of TRPC1 channels is +30 mV.
[8]
The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5.
[9]
[10] The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.
[10]
History
TRPC1 was the first mammalian
Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the
TRP channel in
Drosophila . Together with TRPC3 they became the founding members of the
TRPC
ion channel family.
[5]
[6]
Interactions
TRPC1 has been shown to
interact with:
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000144935 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000032839 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stetten G, Montell C (Oct 1995).
"TRPC1, a human homolog of a Drosophila store-operated channel" . Proceedings of the National Academy of Sciences of the United States of America . 92 (21): 9652–6.
Bibcode :
1995PNAS...92.9652W .
doi :
10.1073/pnas.92.21.9652 .
PMC
40860 .
PMID
7568191 .
^
a
b Zhu X, Chu PB, Peyton M, Birnbaumer L (Oct 1995).
"Molecular cloning of a widely expressed human homologue for the Drosophila trp gene" . FEBS Letters . 373 (3): 193–8.
doi :
10.1016/0014-5793(95)01038-G .
PMID
7589464 .
S2CID
21180202 .
^ Xu SZ, Beech DJ (Jan 2001).
"TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells" . Circulation Research . 88 (1): 84–7.
doi :
10.1161/01.res.88.1.84 .
PMID
11139478 .
^ Skopin A, Shalygin A, Vigont V, Zimina O, Glushankova L, Mozhayeva GN, Kaznacheyeva E (Feb 2013). "TRPC1 protein forms only one type of native store-operated channels in HEK293 cells". Biochimie . 95 (2): 347–53.
doi :
10.1016/j.biochi.2012.10.004 .
PMID
23079337 .
^ Fowler MA, Sidiropoulou K, Ozkan ED, Phillips CW, Cooper DC (2007).
"Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain" . PLOS ONE . 2 (6): e573.
Bibcode :
2007PLoSO...2..573F .
doi :
10.1371/journal.pone.0000573 .
PMC
1892805 .
PMID
17593972 .
^
a
b Cooper, Donald; Fowler, Melissa; Varnell, Andrew; Dietrich, A.; Birnbaumer, L.; Cooper, Donald (2012).
"Deletion of the trpc1 gene and the effects on locomotor and conditioned place-preference responses to cocaine" . Nature Precedings .
doi :
10.1038/npre.2012.7153 .
^ Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003).
"Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors" . Cell . 114 (6): 777–89.
doi :
10.1016/s0092-8674(03)00716-5 .
PMID
14505576 .
S2CID
10552676 .
^ Tsiokas L, Arnould T, Zhu C, Kim E, Walz G, Sukhatme VP (Mar 1999).
"Specific association of the gene product of PKD2 with the TRPC1 channel" . Proceedings of the National Academy of Sciences of the United States of America . 96 (7): 3934–9.
Bibcode :
1999PNAS...96.3934T .
doi :
10.1073/pnas.96.7.3934 .
JSTOR
47742 .
PMC
22398 .
PMID
10097141 .
^ Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB (Aug 2003).
"RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability" . The Journal of Biological Chemistry . 278 (35): 33492–500.
doi :
10.1074/jbc.M302401200 .
PMID
12766172 .
^
a
b
c Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE (Oct 2003).
"Formation of novel TRPC channels by complex subunit interactions in embryonic brain" . The Journal of Biological Chemistry . 278 (40): 39014–9.
doi :
10.1074/jbc.M306705200 .
PMID
12857742 .
^ Xu XZ, Li HS, Guggino WB, Montell C (Jun 1997).
"Coassembly of TRP and TRPL produces a distinct store-operated conductance" . Cell . 89 (7): 1155–64.
doi :
10.1016/s0092-8674(00)80302-5 .
PMID
9215637 .
S2CID
15275438 .
^
a
b Hofmann T, Schaefer M, Schultz G, Gudermann T (May 2002).
"Subunit composition of mammalian transient receptor potential channels in living cells" . Proceedings of the National Academy of Sciences of the United States of America . 99 (11): 7461–6.
Bibcode :
2002PNAS...99.7461H .
doi :
10.1073/pnas.102596199 .
PMC
124253 .
PMID
12032305 .
Further reading
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
TRPA
Activators
4-Hydroxynonenal
4-Oxo-2-nonenal
4,5-EET
12S-HpETE
15-Deoxy-Δ12,14 -prostaglandin J2
α-Sanshool (
ginger ,
Sichuan and
melegueta peppers )
Acrolein
Allicin (
garlic )
Allyl isothiocyanate (
mustard ,
radish ,
horseradish ,
wasabi )
AM404
ASP-7663
Bradykinin
Cannabichromene (
cannabis )
Cannabidiol (
cannabis )
Cannabigerol (
cannabis )
Cinnamaldehyde (
cinnamon )
CR gas (dibenzoxazepine; DBO)
CS gas (2-chlorobenzal malononitrile)
Cuminaldehyde (
cumin )
Curcumin (
turmeric )
Dehydroligustilide (
celery )
Diallyl disulfide
Dicentrine (
Lindera spp.)
Farnesyl thiosalicylic acid
Formalin
Gingerols (
ginger )
Hepoxilin A3
Hepoxilin B3
Hydrogen peroxide
Icilin
Isothiocyanate
JT-010
Ligustilide (
celery ,
Angelica acutiloba )
Linalool (
Sichuan pepper ,
thyme )
Methylglyoxal
Methyl salicylate (
wintergreen )
N-Methylmaleimide
Nicotine (
tobacco )
Oleocanthal (
olive oil )
Paclitaxel (
Pacific yew )
Paracetamol (acetaminophen)
PF-4840154
Phenacyl chloride
Polygodial (
Dorrigo pepper )
Shogaols (
ginger ,
Sichuan and
melegueta peppers )
Tear gases
Tetrahydrocannabinol (
cannabis )
Tetrahydrocannabiorcol
Thiopropanal S-oxide (
onion )
Umbellulone (Umbellularia californica )
WIN 55,212-2
Blockers
TRPC
TRPM
TRPML
TRPP
TRPV
Activators
2-APB
5',6'-EET
9-HODE
9-oxoODE
12S-HETE
12S-HpETE
13-HODE
13-oxoODE
20-HETE
α-Sanshool (
ginger ,
Sichuan and
melegueta peppers )
Allicin (
garlic )
AM404
Anandamide
Bisandrographolide (
Andrographis paniculata )
Camphor (
camphor laurel ,
rosemary ,
camphorweed ,
African blue basil ,
camphor basil )
Cannabidiol (
cannabis )
Cannabidivarin (
cannabis )
Capsaicin (
chili pepper )
Carvacrol (
oregano ,
thyme ,
pepperwort ,
wild bergamot , others)
DHEA
Diacyl glycerol
Dihydrocapsaicin (
chili pepper )
Estradiol
Eugenol (
basil ,
clove )
Evodiamine (
Euodia ruticarpa )
Gingerols (
ginger )
GSK1016790A
Heat
Hepoxilin A3
Hepoxilin B3
Homocapsaicin (
chili pepper )
Homodihydrocapsaicin (
chili pepper )
Incensole (
incense )
Lysophosphatidic acid
Low
pH (acidic conditions)
Menthol (
mint )
N-Arachidonoyl dopamine
N-Oleoyldopamine
N-Oleoylethanolamide
Nonivamide (PAVA) (
PAVA spray )
Nordihydrocapsaicin (
chili pepper )
Paclitaxel (
Pacific yew )
Paracetamol (acetaminophen)
Phenylacetylrinvanil
Phorbol esters (e.g.,
4α-PDD )
Piperine (
black pepper ,
long pepper )
Polygodial (
Dorrigo pepper )
Probenecid
Protons
RhTx
Rutamarin (
Ruta graveolens )
Resiniferatoxin (RTX) (
Euphorbia resinifera /
pooissonii )
Shogaols (
ginger ,
Sichuan and
melegueta peppers )
Tetrahydrocannabivarin (
cannabis )
Thymol (
thyme ,
oregano )
Tinyatoxin (
Euphorbia resinifera /
pooissonii )
Tramadol
Vanillin (
vanilla )
Zucapsaicin
Blockers