From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Potassium channel, subfamily U, member 1 , also known as KCNU1 , is a
gene encoding the KCa 5.1
protein .
[4]
Although this channel is structurally related to the
calcium-activated potassium channels , it cannot be classified as such since it is activated by high
intracellular pH and relatively insensitive to changes in calcium concentrations.
[5]
[6]
[7]
References
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000031576 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998).
"Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes" . J. Biol. Chem . 273 (6): 3509–16.
doi :
10.1074/jbc.273.6.3509 .
PMID
9452476 .
^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol Rev . 57 (4): 463–72.
doi :
10.1124/pr.57.4.9 .
PMID
16382103 .
S2CID
8290401 .
^ Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006).
"pH-regulated Slo3 K+ channels: properties of unitary currents" . J. Gen. Physiol . 128 (3): 301–15.
doi :
10.1085/jgp.200609551 .
PMC
2151565 .
PMID
16940554 .
^ Zhang X, Zeng X, Lingle CJ (September 2006).
"Slo3 K+ channels: voltage and pH dependence of macroscopic currents" . J. Gen. Physiol . 128 (3): 317–36.
doi :
10.1085/jgp.200609552 .
PMC
2151566 .
PMID
16940555 .
Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).
External links
Overview of all the structural information available in the
PDB for
UniProt :
A8MYU2 (Potassium channel subfamily U member 1) at the
PDBe-KB .
Further reading
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65.
doi :
10.1101/gr.4039406 .
PMC
1356129 .
PMID
16344560 .
Schreiber M, Wei A, Yuan A, et al. (1998).
"Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes" . J. Biol. Chem . 273 (6): 3509–16.
doi :
10.1074/jbc.273.6.3509 .
PMID
9452476 .
Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006).
"DNA sequence and analysis of human chromosome 8" . Nature . 439 (7074): 331–5.
Bibcode :
2006Natur.439..331N .
doi :
10.1038/nature04406 .
PMID
16421571 .
Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev . 57 (4): 463–72.
doi :
10.1124/pr.57.4.9 .
PMID
16382103 .
S2CID
8290401 .
Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).