From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Kv channel-interacting protein 1 also known as KChIP1 is a
protein that in humans is encoded by the KCNIP1
gene .
[5]
[6]
Function
This gene encodes a member of the family of voltage-gated potassium (
Kv ) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the
recoverin branch of the
EF-hand superfamily.
[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the
N-terminus . They are integral subunit components of native Kv 4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.
[6]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000182132 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000053519 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature . 403 (6769): 553–556.
Bibcode :
2000Natur.403..553A .
doi :
10.1038/35000592 .
PMID
10676964 .
S2CID
4419472 .
^
a
b
"Entrez Gene: KCNIP1 Kv channel interacting protein 1" .
^ Burgoyne RD (2007).
"Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling" . Nat. Rev. Neurosci . 8 (3): 182–193.
doi :
10.1038/nrn2093 .
PMC
1887812 .
PMID
17311005 .
Further reading
Bähring R, Dannenberg J, Peters HC, et al. (2001).
"Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating" . J. Biol. Chem . 276 (26): 23888–23894.
doi :
10.1074/jbc.M101320200 .
PMID
11287421 .
Nakamura TY, Nandi S, Pountney DJ, et al. (2001).
"Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2" . FEBS Lett . 499 (3): 205–209.
doi :
10.1016/S0014-5793(01)02560-1 .
PMID
11423117 .
S2CID
23908034 .
Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002).
"NotI flanking sequences: a tool for gene discovery and verification of the human genome" . Nucleic Acids Res . 30 (14): 3163–3170.
doi :
10.1093/nar/gkf428 .
PMC
135748 .
PMID
12136098 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Shibata R, Misonou H, Campomanes CR, et al. (2003).
"A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels" . J. Biol. Chem . 278 (38): 36445–36454.
doi :
10.1074/jbc.M306142200 .
PMID
12829703 .
Van Hoorick D, Raes A, Keysers W, et al. (2004). "Differential modulation of Kv4 kinetics by KCHIP1 splice variants". Mol. Cell. Neurosci . 24 (2): 357–366.
doi :
10.1016/S1044-7431(03)00174-X .
PMID
14572458 .
S2CID
40647616 .
Scannevin RH, Wang K, Jow F, et al. (2004).
"Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1" . Neuron . 41 (4): 587–598.
doi :
10.1016/S0896-6273(04)00049-2 .
PMID
14980207 .
S2CID
17380435 .
Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochem. Biophys. Res. Commun . 319 (3): 720–724.
doi :
10.1016/j.bbrc.2004.05.064 .
PMID
15184042 .
Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochem. Biophys. Res. Commun . 321 (3): 606–610.
doi :
10.1016/j.bbrc.2004.07.006 .
PMID
15358149 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Pruunsild P, Timmusk T (2005). "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family". Genomics . 86 (5): 581–593.
doi :
10.1016/j.ygeno.2005.07.001 .
PMID
16112838 .
Pioletti M, Findeisen F, Hura GL, Minor DL (2007).
"Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer" . Nat. Struct. Mol. Biol . 13 (11): 987–995.
doi :
10.1038/nsmb1164 .
PMC
3018330 .
PMID
17057713 . {{
cite journal }}
: CS1 maint: multiple names: authors list (
link )
Hasdemir B, Fitzgerald DJ, Prior IA, Tepikin AV, Burgoyne RD (2005).
"Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway" . J. Cell Biol . 171 (3): 459–469.
doi :
10.1083/jcb.200506005 .
PMC
2171252 .
PMID
16260497 .
Venn N, Haynes LP, Burgoyne RD (2008).
"Specific effects of KChIP3/calsenilin/DREAM but not KChIPs1, 2 and 4 on calcium signalling and regulated secretion in PC12 cells" . Biochem. J . 413 (1): 71–80.
doi :
10.1042/BJ20080441 .
PMC
2474559 .
PMID
18393943 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
PDB gallery
1s1e : Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1)
1s6c : Crystal structure of the complex between KChIP1 and Kv4.2 N1-30
2i2r : Crystal structure of the KChIP1/Kv4.3 T1 complex
2nz0 : Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)