From Wikipedia, the free encyclopedia
Protein-coding gene in humans
Chloride intracellular channel protein 2 is a
protein that in humans is encoded by the CLIC2
gene .
[3]
[4]
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of
intracellular pH , and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti.
[4]
See also
References
Further reading
Thiemann A, Gründer S, Pusch M, Jentsch TJ (1992). "A chloride channel widely expressed in epithelial and non-epithelial cells". Nature . 356 (6364): 57–60.
Bibcode :
1992Natur.356...57T .
doi :
10.1038/356057a0 .
PMID
1311421 .
S2CID
4254798 .
Rogner UC, Heiss NS, Kioschis P, et al. (1997).
"Transcriptional analysis of the candidate region for incontinentia pigmenti (IP2) in Xq28" . Genome Res . 6 (10): 922–34.
doi :
10.1101/gr.6.10.922 .
PMID
8908511 .
Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters . 584 (10): 2112–21.
doi :
10.1016/j.febslet.2010.03.013 .
PMID
20226783 .
S2CID
21056278 .
Hartley JL, Temple GF, Brasch MA (2001).
"DNA Cloning Using In Vitro Site-Specific Recombination" . Genome Res . 10 (11): 1788–95.
doi :
10.1101/gr.143000 .
PMC
310948 .
PMID
11076863 .
Simpson JC, Wellenreuther R, Poustka A, et al. (2001).
"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92.
doi :
10.1093/embo-reports/kvd058 .
PMC
1083732 .
PMID
11256614 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Dhani SU, Mohammad-Panah R, Ahmed N, et al. (2003).
"Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex" . J. Biol. Chem . 278 (18): 16262–70.
doi :
10.1074/jbc.M209828200 .
PMID
12601004 .
Fan L, Yu W, Zhu X (2003).
"Interaction of Sedlin with chloride intracellular channel proteins" . FEBS Lett . 540 (1–3): 77–80.
doi :
10.1016/S0014-5793(03)00228-X .
PMID
12681486 .
S2CID
8573651 .
Board PG, Coggan M, Watson S, et al. (2005). "CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels". Int. J. Biochem. Cell Biol . 36 (8): 1599–612.
doi :
10.1016/j.biocel.2004.01.026 .
PMID
15147738 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Wiemann S, Arlt D, Huber W, et al. (2004).
"From ORFeome to Biology: A Functional Genomics Pipeline" . Genome Res . 14 (10B): 2136–44.
doi :
10.1101/gr.2576704 .
PMC
528930 .
PMID
15489336 .
Ross MT, Grafham DV, Coffey AJ, et al. (2005).
"The DNA sequence of the human X chromosome" . Nature . 434 (7031): 325–37.
Bibcode :
2005Natur.434..325R .
doi :
10.1038/nature03440 .
PMC
2665286 .
PMID
15772651 .
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics . 5 (15): 3876–84.
doi :
10.1002/pmic.200401239 .
PMID
16130169 .
S2CID
26007149 .
Mehrle A, Rosenfelder H, Schupp I, et al. (2006).
"The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8.
doi :
10.1093/nar/gkj139 .
PMC
1347501 .
PMID
16381901 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .