From Wikipedia, the free encyclopedia
Protein-coding gene in humans
Acid-sensing ion channel 1 (ASIC1 ) also known as amiloride-sensitive cation channel 2, neuronal (ACCN2) or brain sodium channel 2 (BNaC2) is a
protein that in humans is encoded by the ASIC1
gene . The ASIC1 gene is one of the five
paralogous genes that encode proteins that form trimeric
acid-sensing ion channels (ASICs) in mammals.
[5] The cDNA of this gene was first cloned in 1996.
[6] The ASIC genes have splicing variants that encode different proteins that are called isoforms.
These genes are mainly expressed in the central and peripheral nervous system.
ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.
[7]
[8]
Structure and function
This gene encodes a member of the ASIC/
ENaC superfamily of proteins.
[9] The members of this family are
amiloride -sensitive
sodium channels that contain
intracellular N and C termini, 2
hydrophobic
transmembrane (TM) regions, and a large
extracellular loop, which has many
cysteine residues with conserved spacing. The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus).
The pore of the channel through which ions selectively flow from the extracellular side into the cytoplasm is formed by the three TM2 regions of the trimer.
[5]
Interactions
ASIC1 has been shown to
interact with
PICK1 .
[10]
[11]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000110881 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000023017 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Hanukoglu I (2017).
"ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters" . FEBS Journal . 284 (4): 525–545.
doi :
10.1111/febs.13840 .
PMID
27580245 .
S2CID
24402104 .
^ García-Añoveros J, Derfler B, Neville-Golden J, Hyman BT, Corey DP (March 1997).
"BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels" . Proc Natl Acad Sci U S A . 94 (4): 1459–64.
Bibcode :
1997PNAS...94.1459G .
doi :
10.1073/pnas.94.4.1459 .
PMC
19813 .
PMID
9037075 .
^ Babinski K, Catarsi S, Biagini G, Séguéla P (Sep 2000).
"Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+" . The Journal of Biological Chemistry . 275 (37): 28519–25.
doi :
10.1074/jbc.M004114200 .
hdl :
11380/304669 .
PMID
10842183 .
^ Bassilana F, Champigny G, Waldmann R, de Weille JR, Heurteaux C, Lazdunski M (Nov 1997).
"The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties" . The Journal of Biological Chemistry . 272 (46): 28819–22.
doi :
10.1074/jbc.272.46.28819 .
PMID
9360943 .
^ Hanukoglu I, Hanukoglu A (Jan 2016).
"Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases" . Gene . 579 (2): 95–132.
doi :
10.1016/j.gene.2015.12.061 .
PMC
4756657 .
PMID
26772908 .
^ Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ (February 2003).
"cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1" .
Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34.
Bibcode :
2003PNAS..100.2029L .
doi :
10.1073/pnas.252782799 .
PMC
149953 .
PMID
12578970 .
^ Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (February 2002).
"Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)" . Biochem. J . 361 (Pt 3): 443–50.
doi :
10.1042/0264-6021:3610443 .
PMC
1222326 .
PMID
11802773 .
Further reading
Corey DP, García-Añoveros J (1996). "Mechanosensation and the DEG/ENaC ion channels". Science . 273 (5273): 323–4.
Bibcode :
1996Sci...273..323C .
doi :
10.1126/science.273.5273.323 .
PMID
8685718 .
S2CID
9015840 .
Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M (1997). "A proton-gated cation channel involved in acid-sensing". Nature . 386 (6621): 173–7.
Bibcode :
1997Natur.386..173W .
doi :
10.1038/386173a0 .
PMID
9062189 .
S2CID
4361943 .
Bubien JK, Keeton DA, Fuller CM, Gillespie GY, Reddy AT, Mapstone TB, Benos DJ (1999). "Malignant human gliomas express an amiloride-sensitive Na+ conductance". Am. J. Physiol . 276 (6 Pt 1): C1405–10.
doi :
10.1152/ajpcell.1999.276.6.C1405 .
PMID
10362604 .
Askwith CC, Cheng C, Ikuma M, Benson C, Price MP, Welsh MJ (2000).
"Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels" . Neuron . 26 (1): 133–41.
doi :
10.1016/S0896-6273(00)81144-7 .
PMID
10798398 .
S2CID
14077330 .
Bässler EL, Ngo-Anh TJ, Geisler HS, Ruppersberg JP, Gründer S (2001).
"Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b" . J. Biol. Chem . 276 (36): 33782–7.
doi :
10.1074/jbc.M104030200 .
PMID
11448963 .
Gunthorpe MJ, Smith GD, Davis JB, Randall AD (2001). "Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells". Pflügers Arch . 442 (5): 668–74.
doi :
10.1007/s004240100584 .
PMID
11512022 .
S2CID
19059975 .
Duggan A, Garcia-Anoveros J, Corey DP (2002).
"The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons" . J. Biol. Chem . 277 (7): 5203–8.
doi :
10.1074/jbc.M104748200 .
PMID
11739374 .
Ji HL, Jovov B, Fu J, Bishop LR, Mebane HC, Fuller CM, Stanton BA, Benos DJ (2002).
"Up-regulation of acid-gated Na(+) channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytes" . J. Biol. Chem . 277 (10): 8395–405.
doi :
10.1074/jbc.M109465200 .
PMID
11748227 .
Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002).
"Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)" . Biochem. J . 361 (Pt 3): 443–50.
doi :
10.1042/0264-6021:3610443 .
PMC
1222326 .
PMID
11802773 .
Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, Nolan BC, Yoder PG, Lamani E, Hoshi T, Freeman JH, Welsh MJ (2002).
"The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory" . Neuron . 34 (3): 463–77.
doi :
10.1016/S0896-6273(02)00661-X .
PMID
11988176 .
S2CID
2619519 .
Berdiev BK, Xia J, Jovov B, Markert JM, Mapstone TB, Gillespie GY, Fuller CM, Bubien JK, Benos DJ (2003).
"Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function" . J. Biol. Chem . 277 (48): 45734–40.
doi :
10.1074/jbc.M208995200 .
PMID
12244121 .
Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, Shimada S (2002).
"Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors" . J. Clin. Invest . 110 (8): 1185–90.
doi :
10.1172/JCI15709 .
PMC
150796 .
PMID
12393854 .
Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ (2003).
"cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1" . Proc. Natl. Acad. Sci. U.S.A . 100 (4): 2029–34.
Bibcode :
2003PNAS..100.2029L .
doi :
10.1073/pnas.252782799 .
PMC
149953 .
PMID
12578970 .
Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ (2004).
"Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior" . Proc. Natl. Acad. Sci. U.S.A . 101 (10): 3621–6.
Bibcode :
2004PNAS..101.3621W .
doi :
10.1073/pnas.0308753101 .
PMC
373512 .
PMID
14988500 .
Poirot O, Vukicevic M, Boesch A, Kellenberger S (2004).
"Selective regulation of acid-sensing ion channel 1 by serine proteases" . J. Biol. Chem . 279 (37): 38448–57.
doi :
10.1074/jbc.M407381200 .
PMID
15247234 .
Price MP, Thompson RJ, Eshcol JO, Wemmie JA, Benson CJ (2005).
"Stomatin modulates gating of acid-sensing ion channels" . J. Biol. Chem . 279 (51): 53886–91.
doi :
10.1074/jbc.M407708200 .
PMID
15471860 .
External links