From Wikipedia, the free encyclopedia
Protein-coding gene in humans
Methylosome subunit pICln is a
protein that in humans is encoded by the CLNS1A
gene .
[5]
[6]
[7]
Interactions
CLNS1A has been shown to
interact with:
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000074201 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000025439 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Anguita J, Chalfant ML, Civan MM, Coca-Prados M (Apr 1995). "Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium". Biochem Biophys Res Commun . 208 (1): 89–95.
doi :
10.1006/bbrc.1995.1309 .
PMID
7887970 .
^ Nagl UO, Erdel M, Schmarda A, Seri M, Pinggera GM, Gschwentner M, Duba C, Galietta LJ, Deetjen P, Utermann G, Paulmichl M (Mar 1997). "Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln". Genomics . 38 (3): 438–41.
doi :
10.1006/geno.1996.0651 .
PMID
8975725 .
^
"Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A" .
^ Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N (Jun 2004).
"ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation" . J. Biol. Chem . 279 (26): 27286–93.
doi :
10.1074/jbc.M402159200 .
PMID
15075326 .
^
a
b
c Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G,
Rappsilber J , Mann M, Dreyfuss G (Dec 2001).
"The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins" . Mol. Cell. Biol . 21 (24): 8289–300.
doi :
10.1128/MCB.21.24.8289-8300.2001 .
PMC
99994 .
PMID
11713266 .
^ Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE (May 1998).
"pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology" . J. Biol. Chem . 273 (18): 10811–4.
doi :
10.1074/jbc.273.18.10811 .
PMID
9556550 .
^ Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002).
"A novel WD repeat protein component of the methylosome binds Sm proteins" . J. Biol. Chem . 277 (10): 8243–7.
doi :
10.1074/jbc.M109984200 .
PMID
11756452 .
^ Krzyzanowski A, Gasper R, Adihou H, 't Hart P, Waldmann H (Feb 2021).
"Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex" . ChemBioChem . 22 (11): 1908–1914.
doi :
10.1002/cbic.202100079 .
PMC
8252068 .
PMID
33624332 .
Further reading
Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P (2006).
"New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium" . Front. Biosci . 11 : 1646–66.
doi :
10.2741/1911 .
PMID
16368544 .
S2CID
26325962 .
Buyse G, de Greef C, Raeymaekers L, Droogmans G, Nilius B, Eggermont J (1996).
"The ubiquitously expressed pICln protein forms homomeric complexes in vitro" . Biochem. Biophys. Res. Commun . 218 (3): 822–7.
doi :
10.1006/bbrc.1996.0146 .
PMID
8579598 .
Schwartz RS, Rybicki AC, Nagel RL (1997).
"Molecular cloning and expression of a chloride channel-associated protein pICln in human young red blood cells: association with actin" . Biochem. J . 327 (2): 609–16.
doi :
10.1042/bj3270609 .
PMC
1218836 .
PMID
9359436 .
Bekri S, Adélaïde J, Merscher S, Grosgeorge J, Caroli-Bosc F, Perucca-Lostanlen D, Kelley PM, Pébusque MJ, Theillet C, Birnbaum D, Gaudray P (1998). "Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma". Cytogenet. Cell Genet . 79 (1–2): 125–31.
doi :
10.1159/000134699 .
PMID
9533029 .
Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE (1998).
"pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology" . J. Biol. Chem . 273 (18): 10811–4.
doi :
10.1074/jbc.273.18.10811 .
PMID
9556550 .
Tang CJ, Tang TK (1998). "The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein involved in cellular volume regulation". Blood . 92 (4): 1442–7.
doi :
10.1182/blood.V92.4.1442 .
PMID
9694734 .
Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE (1999).
"pICln inhibits snRNP biogenesis by binding core spliceosomal proteins" . Mol. Cell. Biol . 19 (6): 4113–20.
doi :
10.1128/MCB.19.6.4113 .
PMC
104370 .
PMID
10330151 .
Hubert MD, Levitan I, Hoffman MM, Zraggen M, Hofreiter ME, Garber SS (2000).
"Modulation of volume regulated anion current by I(Cln)" . Biochim. Biophys. Acta . 1466 (1–2): 105–14.
doi :
10.1016/S0005-2736(00)00177-2 .
PMID
10825435 .
Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (2001).
"The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins" . Mol. Cell. Biol . 21 (24): 8289–300.
doi :
10.1128/MCB.21.24.8289-8300.2001 .
PMC
99994 .
PMID
11713266 .
Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U (2002). "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln". Curr. Biol . 11 (24): 1990–4.
doi :
10.1016/S0960-9822(01)00592-9 .
hdl :
11858/00-001M-0000-0012-F501-7 .
PMID
11747828 .
S2CID
14742376 .
Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002).
"A novel WD repeat protein component of the methylosome binds Sm proteins" . J. Biol. Chem . 277 (10): 8243–7.
doi :
10.1074/jbc.M109984200 .
PMID
11756452 .
Meyer G, Rodighiero S, Guizzardi F, Bazzini C, Bottà G, Bertocchi C, Garavaglia L, Dossena S, Manfredi R, Sironi C, Catania A, Paulmichl M (2004). "Volume-regulated Cl− channels in human pleural mesothelioma cells". FEBS Lett . 559 (1–3): 45–50.
doi :
10.1016/S0014-5793(04)00020-1 .
PMID
14960305 .
S2CID
24747269 .
Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N (2004).
"ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation" . J. Biol. Chem . 279 (26): 27286–93.
doi :
10.1074/jbc.M402159200 .
PMID
15075326 .
Fürst J, Schedlbauer A, Gandini R, Garavaglia ML, Saino S, Gschwentner M, Sarg B, Lindner H, Jakab M, Ritter M, Bazzini C, Botta G, Meyer G, Kontaxis G, Tilly BC, Konrat R, Paulmichl M (2005).
"ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4" . J. Biol. Chem . 280 (35): 31276–82.
doi :
10.1074/jbc.M500541200 .
PMID
15905169 .
Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D (2005).
"Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes" . J. Biol. Chem . 280 (41): 34435–40.
doi :
10.1074/jbc.M505077200 .
hdl :
21.11116/0000-0007-E5F1-6 .
PMID
16087681 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .