Mucolipin-2 also known as TRPML2 (transient receptor potential cation channel, mucolipin subfamily, member 2) is a protein that in humans is encoded by the MCOLN2 gene. [5] It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.
TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport of membranes and membrane proteins. [6]
See also
- transient receptor potential cation channel, mucolipin subfamily, member 1 ( MCOLN1)
- transient receptor potential cation channel, mucolipin subfamily, member 3 ( MCOLN3)
- TRPML
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000153898 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011008 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi: 10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
- ^ Karacsonyi C, Miguel AS, Puertollano R (October 2007). "Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs". Traffic. 8 (10): 1404–14. doi: 10.1111/j.1600-0854.2007.00619.x. PMID 17662026. S2CID 25624298.
External links
- MCOLN2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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