This gene encodes an alpha-1 subunit of a voltage-dependent
calcium channel. Calcium channels mediate the influx of calcium
ions (Ca2+) into the
cell upon membrane polarization (see
membrane potential and
calcium in biology).[7]
The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta and beta subunits in a 1:1:1 ratio. The S3-S4 linkers of Cav1.2 determine the gating phenotype and modulated gating kinetics of the channel.[8] Cav1.2 is widely expressed in the
smooth muscle,
pancreatic cells,
fibroblasts, and
neurons.[9][10] However, it is particularly important and well known for its expression in the heart where it mediates L-type currents, which causes calcium-induced calcium release from the ER Stores via
ryanodine receptors. It depolarizes at -30
mV and helps define the shape of the action potential in
cardiac and smooth muscle.[8] The protein encoded by this gene binds to and is inhibited by
dihydropyridine.[11] In the arteries of the brain, high levels of calcium in mitochondria elevates activity of nuclear factor kappa B
NF-κB and transcription of CACNA1c and functional Cav1.2 expression increases.[12] Cav1.2 also regulates levels of
osteoprotegerin.[13]
The activity of CaV1.2 channels is tightly regulated by the Ca2+ signals they produce. An increase in intracellular Ca2+ concentration implicated in Cav1.2 facilitation, a form of positive feedback called Ca2+-dependent facilitation, that amplifies Ca2+ influx. In addition, increasing influx intracellular Ca2+ concentration has implicated to exert the opposite effect Ca2+ dependent inactivation.[15] These activation and inactivation mechanisms both involve Ca2+ binding to calmodulin (CaM) in the IQ domain in the C-terminal tail of these channels.[16] Cav1.2 channels are arranged in cluster of eight, on average, in the cell membrane. When calcium ions bind to calmodulin, which in turn binds to a Cav1.2 channel, it allows the Cav1.2 channels within a cluster to interact with each other.[17] This results in channels working cooperatively when they open at the same time to allow more calcium ions to enter and then close together to allow the cell to relax.[17]
Clinical significance
Mutation in the CACNA1C gene, the
single-nucleotide polymorphism located in the third intron of the Cav1.2 gene,[18] are associated with a variant of
Long QT syndrome called
Timothy's syndrome[19] and more broadly with other
CACNA1C-related disorders,[19] and also with
Brugada syndrome.[20] Large-scale genetic analyses have shown the possibility that CACNA1C is associated with
bipolar disorder[21] and subsequently also with
schizophrenia.[22][23][24] Also, a CACNA1C risk allele has been associated to a disruption in brain connectivity in patients with bipolar disorder, while not or only to a minor degree, in their unaffected relatives or healthy controls.[25].In a first study in Indian population, the Schizophrenia associated
Genome-wide association study (GWAS) SNP was found not to be associated with the disease. Furthermore, the main effect of rs1006737 was found to be associated with spatial abilityefficiency scores. Subjects with genotypes carrying the risk allele of rs1006737 (G/A and A/A) were found to have higher spatial abilityefficiency scores as compared to those with the G/G genotype. While in healthy controls those with G/A and A/A genotypes were found to have higher spatial memoryprocessing speed scores than those with G/G genotypes, the former had lower scores than the latter in schizophrenia subjects. In the same study the genotypes with the risk allele of rs1006737 namely A/A was associated with a significantly lower Align rank transformed Abnormal and involuntary movement scale(AIMS) scores of
Tardive dyskinesia(TD).[26]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective Wikipedia articles.[§ 1]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lacerda AE, Kim HS, Ruth P, Perez-Reyes E, Flockerzi V, Hofmann F, Birnbaumer L, Brown AM (Aug 1991). "Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel". Nature. 352 (6335): 527–30.
Bibcode:
1991Natur.352..527L.
doi:
10.1038/352527a0.
PMID1650913.
S2CID4246540.
^Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (Dec 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacological Reviews. 57 (4): 411–25.
doi:
10.1124/pr.57.4.5.
PMID16382099.
S2CID10386627.
^Berger SM, Bartsch D (Aug 2014). "The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function". Cell and Tissue Research. 357 (2): 463–76.
doi:
10.1007/s00441-014-1936-3.
PMID24996399.
S2CID15914718.
^Punchaichira TJ, Kukshal P, Bhatia T, Deshpande SN (2023). "Effect of rs1108580 of DBH and rs1006737 of CACNA1C on Cognition and Tardive Dyskinesia in a North Indian Schizophrenia Cohort". Molecular Neurobiology. 60 (12): 6826–6839.
doi:
10.1007/s12035-023-03496-4.
PMID37493923.
S2CID260162784.
Further reading
Kempton MJ, Ruberto G, Vassos E, Tatarelli R, Girardi P, Collier D, Frangou S (Dec 2009). "Effects of the CACNA1C risk allele for bipolar disorder on cerebral gray matter volume in healthy individuals". The American Journal of Psychiatry. 166 (12): 1413–4.
doi:
10.1176/appi.ajp.2009.09050680.
PMID19952088.
Powers PA, Gregg RG, Hogan K (Sep 1992). "Linkage mapping of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CACNL1A1) to chromosome 12p13.2-pter using a dinucleotide repeat". Genomics. 14 (1): 206–7.
doi:
10.1016/S0888-7543(05)80312-X.
PMID1330882.
Sun W, McPherson JD, Hoang DQ, Wasmuth JJ, Evans GA, Montal M (Dec 1992). "Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter". Genomics. 14 (4): 1092–4.
doi:
10.1016/S0888-7543(05)80135-1.
PMID1335957.
Powers PA, Gregg RG, Lalley PA, Liao M, Hogan K (Jul 1991). "Assignment of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CCHL1A1) to chromosome 12p12-pter". Genomics. 10 (3): 835–9.
doi:
10.1016/0888-7543(91)90471-P.
PMID1653763.
Perets T, Blumenstein Y, Shistik E, Lotan I, Dascal N (Apr 1996). "A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit". FEBS Letters. 384 (2): 189–92.
doi:
10.1016/0014-5793(96)00303-1.
PMID8612821.
S2CID40550657.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13.
doi:
10.1006/abio.1996.0138.
PMID8619474.
Klöckner U, Mikala G, Eisfeld J, Iles DE, Strobeck M, Mershon JL, Schwartz A, Varadi G (Mar 1997). "Properties of three COOH-terminal splice variants of a human cardiac L-type Ca2+-channel alpha1-subunit". The American Journal of Physiology. 272 (3 Pt 2): H1372–81.
doi:
10.1152/ajpheart.1997.272.3.H1372.
PMID9087614.
Zühlke RD, Bouron A, Soldatov NM, Reuter H (May 1998). "Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene". FEBS Letters. 427 (2): 220–4.
doi:
10.1016/S0014-5793(98)00425-6.
PMID9607315.
S2CID32580111.