From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Short transient receptor potential channel 5 (TrpC5 ) also known as transient receptor protein 5 (TRP-5 ) is a
protein that in humans is encoded by the TRPC5
gene .
[5]
[6]
[7] TrpC5 is subtype of the
TRPC family of
mammalian
transient receptor potential
ion channels .
Function
TrpC5 is one of the seven mammalian
TRPC (transient receptor potential canonical) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with
TRPC1 ,
TRPC3 , and
TRPC4 . It also interacts with multiple proteins including
calmodulin ,
CABP1 ,
enkurin , Na+ –H+ exchange regulatory factor (
NHERF ), interferon-induced GTP-binding protein (
MX1 ), ring finger protein 24 (
RNF24 ), and
SEC14 domain and spectrin repeat-containing protein 1 (
SESTD1 ).
[5]
TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity
[8] and neurological behavior.
[9] It was established in 2021 that TRPC5 is a component of the dental cold sensing system.
[10]
Activation
Homomultimeric TRPC5 and heteromultimeric TRPC5-
TRPC1 channels are activated by extracellular reduced
thioredoxin .
[11] This channel has also been found to be involved in the action of anaesthetics such as
chloroform ,
halothane and
propofol .
[12]
Interactions
TRPC5 has been shown to
interact with
STMN3 ,
[13]
TRPC1 ,
[14]
[15] and
TRPC4 .
[15]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000072315 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000041710 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
"Entrez Gene: transient receptor potential cation channel" .
^ Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK (September 1999). "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel". Genomics . 60 (3): 330–40.
doi :
10.1006/geno.1999.5924 .
PMID
10493832 .
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev . 57 (4): 427–50.
doi :
10.1124/pr.57.4.6 .
PMID
16382100 .
S2CID
17936350 .
^ Xu SZ, Zeng B, Daskoulidou N, Chen GL, Atkin SL, Lukhele B (January 2012).
"Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure" . Toxicol. Sci . 125 (1): 56–68.
doi :
10.1093/toxsci/kfr268 .
PMID
21984481 .
^ Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE (May 15, 2009).
"Essential role for TRPC5 in amygdala function and fear-related behavior" . Cell . 137 (4): 761–72.
doi :
10.1016/j.cell.2009.03.039 .
PMC
2719954 .
PMID
19450521 .
^ Bernal L, Sotelo-Hitschfeld P, König C, Sinica V, Wyatt A, Winter Z, Hein A, Touska F, Reinhardt S, Tragl A, Kusuda R, Wartenberg P, Sclaroff A, Pfeifer JD, Ectors F, Dahl A, Freichel M, Vlachova V, Brauchi S, Roza C, Boehm U, Clapham DE, Lennerz JK, Zimmermann K (2021).
"Odontoblast TRPC5 channels signal cold pain in teeth" . Science Advances . 7 (13): eabf5567.
doi :
10.1126/sciadv.abf5567 .
PMC
7997515 .
PMID
33771873 .
^ Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, Al-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ (January 2008).
"TRPC channel activation by extracellular thioredoxin" . Nature . 451 (7174): 69–72.
doi :
10.1038/nature06414 .
PMC
2645077 .
PMID
18172497 .
^ Bahnasi YM, Wright HM, Milligan CJ, Dedman AM, Zeng F, Hopkins PM, Bateson AN, Beech DJ (April 2008).
"Modulation of TRPC5 cation channels by halothane, chloroform and propofol" . Br. J. Pharmacol . 153 (7): 1505–12.
doi :
10.1038/sj.bjp.0707689 .
PMC
2437913 .
PMID
18204473 .
^ Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (August 2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nat. Neurosci . 6 (8): 837–45.
doi :
10.1038/nn1092 .
PMID
12858178 .
S2CID
7523946 .
^ Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE (October 2003).
"Formation of novel TRPC channels by complex subunit interactions in embryonic brain" . J. Biol. Chem . 278 (40): 39014–9.
doi :
10.1074/jbc.M306705200 .
PMID
12857742 .
^
a
b Hofmann T, Schaefer M, Schultz G, Gudermann T (May 2002).
"Subunit composition of mammalian transient receptor potential channels in living cells" . Proc. Natl. Acad. Sci. U.S.A . 99 (11): 7461–6.
Bibcode :
2002PNAS...99.7461H .
doi :
10.1073/pnas.102596199 .
PMC
124253 .
PMID
12032305 .
Further reading
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
TRPA
Activators
4-Hydroxynonenal
4-Oxo-2-nonenal
4,5-EET
12S-HpETE
15-Deoxy-Δ12,14 -prostaglandin J2
α-Sanshool (
ginger ,
Sichuan and
melegueta peppers )
Acrolein
Allicin (
garlic )
Allyl isothiocyanate (
mustard ,
radish ,
horseradish ,
wasabi )
AM404
ASP-7663
Bradykinin
Cannabichromene (
cannabis )
Cannabidiol (
cannabis )
Cannabigerol (
cannabis )
Cinnamaldehyde (
cinnamon )
CR gas (dibenzoxazepine; DBO)
CS gas (2-chlorobenzal malononitrile)
Cuminaldehyde (
cumin )
Curcumin (
turmeric )
Dehydroligustilide (
celery )
Diallyl disulfide
Dicentrine (
Lindera spp.)
Farnesyl thiosalicylic acid
Formalin
Gingerols (
ginger )
Hepoxilin A3
Hepoxilin B3
Hydrogen peroxide
Icilin
Isothiocyanate
JT-010
Ligustilide (
celery ,
Angelica acutiloba )
Linalool (
Sichuan pepper ,
thyme )
Methylglyoxal
Methyl salicylate (
wintergreen )
N-Methylmaleimide
Nicotine (
tobacco )
Oleocanthal (
olive oil )
Paclitaxel (
Pacific yew )
Paracetamol (acetaminophen)
PF-4840154
Phenacyl chloride
Polygodial (
Dorrigo pepper )
Shogaols (
ginger ,
Sichuan and
melegueta peppers )
Tear gases
Tetrahydrocannabinol (
cannabis )
Tetrahydrocannabiorcol
Thiopropanal S-oxide (
onion )
Umbellulone (Umbellularia californica )
WIN 55,212-2
Blockers
TRPC
TRPM
TRPML
TRPP
TRPV
Activators
2-APB
5',6'-EET
9-HODE
9-oxoODE
12S-HETE
12S-HpETE
13-HODE
13-oxoODE
20-HETE
α-Sanshool (
ginger ,
Sichuan and
melegueta peppers )
Allicin (
garlic )
AM404
Anandamide
Bisandrographolide (
Andrographis paniculata )
Camphor (
camphor laurel ,
rosemary ,
camphorweed ,
African blue basil ,
camphor basil )
Cannabidiol (
cannabis )
Cannabidivarin (
cannabis )
Capsaicin (
chili pepper )
Carvacrol (
oregano ,
thyme ,
pepperwort ,
wild bergamot , others)
DHEA
Diacyl glycerol
Dihydrocapsaicin (
chili pepper )
Estradiol
Eugenol (
basil ,
clove )
Evodiamine (
Euodia ruticarpa )
Gingerols (
ginger )
GSK1016790A
Heat
Hepoxilin A3
Hepoxilin B3
Homocapsaicin (
chili pepper )
Homodihydrocapsaicin (
chili pepper )
Incensole (
incense )
Lysophosphatidic acid
Low
pH (acidic conditions)
Menthol (
mint )
N-Arachidonoyl dopamine
N-Oleoyldopamine
N-Oleoylethanolamide
Nonivamide (PAVA) (
PAVA spray )
Nordihydrocapsaicin (
chili pepper )
Paclitaxel (
Pacific yew )
Paracetamol (acetaminophen)
Phenylacetylrinvanil
Phorbol esters (e.g.,
4α-PDD )
Piperine (
black pepper ,
long pepper )
Polygodial (
Dorrigo pepper )
Probenecid
Protons
RhTx
Rutamarin (
Ruta graveolens )
Resiniferatoxin (RTX) (
Euphorbia resinifera /
pooissonii )
Shogaols (
ginger ,
Sichuan and
melegueta peppers )
Tetrahydrocannabivarin (
cannabis )
Thymol (
thyme ,
oregano )
Tinyatoxin (
Euphorbia resinifera /
pooissonii )
Tramadol
Vanillin (
vanilla )
Zucapsaicin
Blockers