Kcnk10

KCNK10
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4BW5, 4XDJ, 4XDK, 4XDL
Identifiers
Aliases	KCNK10, K2p10.1, PPP1R97, TREK-2, TREK2, potassium two pore domain channel subfamily K member 10
External IDs	OMIM: 605873; MGI: 1919508; HomoloGene: 11321; GeneCards: KCNK10; OMA: KCNK10 - orthologs
Gene location ( Human)
Chr.	Chromosome 14 (human)
End	88,326,907 bp
Gene location ( Mouse)
Chr.	Chromosome 12 (mouse)
End	98,544,569 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; pons; ; ventricular zone; ; Brodmann area 23; ; superior vestibular nucleus; ; ventral tegmental area; ; jejunal mucosa; ; dorsal motor nucleus of vagus nerve; ; parietal lobe; ; inferior olivary nucleus;
	Top expressed in
	ventricular zone; ; spermatocyte; ; lumbar spinal ganglion; ; ganglionic eminence; ; medial ganglionic eminence; ; cerebellar cortex; ; neural tube; ; trigeminal ganglion; ; mesencephalon; ; lobe of cerebellum;
	More reference expression data
	n/a
Gene ontology
Molecular function	potassium channel activity; voltage-gated ion channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; memory; ion transport; signal transduction; stabilization of membrane potential; potassium ion transmembrane transport;
	Sources: Amigo / QuickGO
Orthologs
	54207
	72258
	ENSG00000100433
	ENSMUSG00000033854
	P57789
	n/a
	NM_021161; NM_138317; NM_138318
	NM_029911; NM_001316664; NM_001316665; NM_001316666
	NP_066984; NP_612190; NP_612191
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel, subfamily K, member 10, also known as KCNK10 is a human gene. The protein encoded by this gene, K_2P10.1, is a potassium channel containing two pore-forming P domains.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100433 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033854 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lesage F, Terrenoire C, Romey G, Lazdunski M (September 2000). "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors". The Journal of Biological Chemistry. 275 (37): 28398–405. doi: 10.1074/jbc.M002822200. PMID 10880510.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacological Reviews. 57 (4): 527–40. doi: 10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP (March 2015). "K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac". Science. 347 (6227): 1256–9. Bibcode: 2015Sci...347.1256D. doi: 10.1126/science.1261512. PMC 6034649. PMID 25766236.

External links

KCNK10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100433 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033854 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10880510-5] Lesage F, Terrenoire C, Romey G, Lazdunski M (September 2000). "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors". The Journal of Biological Chemistry. 275 (37): 28398–405. doi: 10.1074/jbc.M002822200. PMID 10880510.

[pmid16382106-6] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacological Reviews. 57 (4): 527–40. doi: 10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[pmid25766236-7] Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP (March 2015). "K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac". Science. 347 (6227): 1256–9. Bibcode: 2015Sci...347.1256D. doi: 10.1126/science.1261512. PMC 6034649. PMID 25766236.

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See also

References

Further reading

External links