Chloride channel accessory 4, also known as CLCA4, is a
protein which in humans CLCA4gene. The
protein encoded by this gene is a
chloride channel.[5] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc
metalloprotease, and the protein is not an ion channel per se.[6]
^Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39.
doi:
10.1002/prot.20887.
PMID16470849.
S2CID40041491.
Ritzka M, Stanke F, Jansen S, et al. (2004). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis". Hum. Genet. 115 (6): 483–91.
doi:
10.1007/s00439-004-1190-y.
PMID15490240.
S2CID12935280.
Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2000). "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5.
doi:
10.1046/j.1440-1681.2000.03358.x.
PMID11071307.
S2CID28762005.