From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Inositol 1,4,5-trisphosphate receptor, type 3 , also known as ITPR3 , is a
protein which in humans is encoded by the ITPR3
gene .
[5] The
protein encoded by this gene is both a
receptor for
inositol triphosphate and a
calcium channel .
[6]
Function
ITP3 channels serve an important role in the taste transduction pathway of
sweet ,
bitter and
umami tastes the
gustatory system . ITP3 channels allow the flow of Calcium out of the
endoplasmic reticulum in response to IP3. Calcium cations result in the activation of
TRPM5 which leads to a depolarisation generating potential and an
action potential .
[7]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000096433 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000042644 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: inositol 1" .
^ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels . 2 (1): 9–22.
PMID
8081734 .
^ Chaudhari N, Roper SD (August 2010).
"The cell biology of taste" . J. Cell Biol . 190 (3): 285–96.
doi :
10.1083/jcb.201003144 .
PMC
2922655 .
PMID
20696704 .
Further reading
Kline CF, Cunha SR, Lowe JS, et al. (2008).
"Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor" . J. Cell. Biochem . 104 (4): 1244–53.
doi :
10.1002/jcb.21704 .
PMC
2858327 .
PMID
18275062 .
Oishi T, Iida A, Otsubo S, et al. (2008).
"A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population" . J. Hum. Genet . 53 (2): 151–62.
doi :
10.1007/s10038-007-0233-3 .
PMID
18219441 .
Hirose M, Stuyvers B, Dun W, et al. (2008).
"Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells" . J. Mol. Cell. Cardiol . 45 (2): 176–84.
doi :
10.1016/j.yjmcc.2008.05.008 .
PMC
2566512 .
PMID
18586264 .
Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases". Mod Rheumatol . 17 (2): 137–43.
doi :
10.1007/s10165-006-0555-6 .
PMID
17437169 .
S2CID
36516047 .
Tang TS, Guo C, Wang H, et al. (2009).
"Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model" . J. Neurosci . 29 (5): 1257–66.
doi :
10.1523/JNEUROSCI.4411-08.2009 .
PMC
2768402 .
PMID
19193873 .
Nagaleekar VK, Diehl SA, Juncadella I, et al. (2008).
"IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program" . J. Immunol . 181 (12): 8315–22.
doi :
10.4049/jimmunol.181.12.8315 .
PMC
2756541 .
PMID
19050248 .
Bandyopadhyay BC, Swaim WD, Liu X, et al. (2005).
"Apical localization of a functional TRPC3/TRPC6-Ca2+ -signaling complex in polarized epithelial cells. Role in apical Ca2+ influx" . J. Biol. Chem . 280 (13): 12908–16.
doi :
10.1074/jbc.M410013200 .
PMID
15623527 .
Kasri NN, Holmes AM, Bultynck G, et al. (2004).
"Regulation of InsP3 receptor activity by neuronal Ca2+ -binding proteins" . EMBO J . 23 (2): 312–21.
doi :
10.1038/sj.emboj.7600037 .
PMC
1271747 .
PMID
14685260 .
Hattori M, Suzuki AZ, Higo T, et al. (2004).
"Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling" . J. Biol. Chem . 279 (12): 11967–75.
doi :
10.1074/jbc.M311456200 .
PMID
14707143 .
Olsen JV, Blagoev B, Gnad F, et al. (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .
Roach JC, Deutsch K, Li S, et al. (2006).
"Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden" . Am. J. Hum. Genet . 79 (4): 614–27.
doi :
10.1086/507876 .
PMC
1592562 .
PMID
16960798 .
Tojyo Y, Morita T, Nezu A, Tanimura A (2008).
"The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca2+ store" . J. Pharmacol. Sci . 107 (2): 138–50.
doi :
10.1254/jphs.08021FP .
PMID
18544901 .
Singleton PA, Bourguignon LY (2004). "CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation". Exp. Cell Res . 295 (1): 102–18.
doi :
10.1016/j.yexcr.2003.12.025 .
PMID
15051494 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Ogasawara H (2008).
"The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection" . J. Neurosci . 28 (17): 4293–4.
doi :
10.1523/JNEUROSCI.0644-08.2008 .
PMC
6670947 .
PMID
18434505 .
Qu HQ, Marchand L, Szymborski A, et al. (2008). "The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II". Genes Immun . 9 (3): 264–6.
doi :
10.1038/gene.2008.12 .
PMID
18340361 .
S2CID
8563179 .
Wu Z, Bowen WD (2008).
"Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells" . J. Biol. Chem . 283 (42): 28198–215.
doi :
10.1074/jbc.M802099200 .
PMC
2661391 .
PMID
18539593 .
Martínez-Gámez A, Dent MA (2007). "Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve". NeuroReport . 18 (5): 447–50.
doi :
10.1097/WNR.0b013e32805868a6 .
PMID
17496801 .
S2CID
28136973 .
Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA (2008).
"IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site" . J. Biol. Chem . 283 (46): 31284–8.
doi :
10.1074/jbc.C800184200 .
PMID
18826956 .
Sundivakkam PC, Kwiatek AM, Sharma TT, et al. (2009).
"Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells" . Am. J. Physiol., Cell Physiol . 296 (3): C403–13.
doi :
10.1152/ajpcell.00470.2008 .
PMC
2660268 .
PMID
19052258 .
External links