From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
CLIC1
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
1K0M ,
1K0N ,
1K0O ,
1RK4 ,
3O3T ,
3P8W ,
3P90 ,
3QR6 ,
3SWL ,
3TGZ ,
3UVH ,
4IQA ,
4JZQ ,
4K0G ,
4K0N
Identifiers
Aliases
CLIC1 , G6, NCC27, chloride intracellular channel 1, CL1C1, CLCNL1External IDs
OMIM :
602872 ;
MGI :
2148924 ;
HomoloGene :
20343 ;
GeneCards :
CLIC1 ;
OMA :
CLIC1 - orthologs
Wikidata
Chloride intracellular channel protein 1 is a
protein that in humans is encoded by the CLIC1
gene .
[5]
[6]
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of
intracellular pH , and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
[6]
Interactions
CLIC1 has been shown to
interact with
TRAPPC2 .
[7]
See also
References
^
a
b
c
ENSG00000223639, ENSG00000226248, ENSG00000226651, ENSG00000226417, ENSG00000230685, ENSG00000206394 GRCh38: Ensembl release 89: ENSG00000213719, ENSG00000223639, ENSG00000226248, ENSG00000226651, ENSG00000226417, ENSG00000230685, ENSG00000206394 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000007041 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN (Jun 1997).
"Molecular cloning and expression of a chloride ion channel of cell nuclei" . J Biol Chem . 272 (19): 12575–82.
doi :
10.1074/jbc.272.19.12575 .
PMID
9139710 .
^
a
b
"Entrez Gene: CLIC1 chloride intracellular channel 1" .
^ Fan L, Yu Wei, Zhu Xueliang (Apr 2003).
"Interaction of Sedlin with chloride intracellular channel proteins" . FEBS Lett . 540 (1–3). Netherlands: 77–80.
doi :
10.1016/S0014-5793(03)00228-X .
ISSN
0014-5793 .
PMID
12681486 .
S2CID
8573651 .
Further reading
Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters . 584 (10): 2112–21.
doi :
10.1016/j.febslet.2010.03.013 .
PMID
20226783 .
S2CID
21056278 .
Okubo K, Hori N, Matoba R, et al. (1994). "Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression". Nat. Genet . 2 (3): 173–9.
doi :
10.1038/ng1192-173 .
PMID
1345164 .
S2CID
35309579 .
Frigerio JM, Berthézène P, Garrido P, et al. (1995). "Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing". Hum. Mol. Genet . 4 (1): 37–43.
doi :
10.1093/hmg/4.1.37 .
PMID
7711732 .
Singh H, Ashley RH (2006).
"Redox Regulation of CLIC1 by Cysteine Residues Associated with the Putative Channel Pore" . Biophys. J . 90 (5): 1628–1638.
Bibcode :
2006BpJ....90.1628S .
doi :
10.1529/biophysj.105.072678 .
PMC
1367314 .
PMID
16339885 .
Liew CC, Hwang DM, Fung YW, et al. (1994).
"A catalogue of genes in the cardiovascular system as identified by expressed sequence tags" . Proc. Natl. Acad. Sci. U.S.A . 91 (22): 10645–9.
Bibcode :
1994PNAS...9110645L .
doi :
10.1073/pnas.91.22.10645 .
PMC
45078 .
PMID
7938007 .
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 .
Heiss NS, Poustka A (1997). "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28". Genomics . 45 (1): 224–8.
doi :
10.1006/geno.1997.4922 .
PMID
9339381 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 .
Tulk BM, Edwards JC (1998).
"NCC27, a homolog of intracellular Cl− channel p64, is expressed in brush border of renal proximal tubule" . Am. J. Physiol . 274 (6 Pt 2): F1140–9.
doi :
10.1152/ajprenal.1998.274.6.F1140 .
PMID
9841507 .
S2CID
39652235 .
Chuang JZ, Milner TA, Zhu M, Sung CH (1999).
"A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons" . J. Neurosci . 19 (8): 2919–28.
doi :
10.1523/JNEUROSCI.19-08-02919.1999 .
PMC
6782274 .
PMID
10191309 .
Ribas G, Neville M, Wixon JL, et al. (1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J. Immunol . 163 (1): 278–87.
doi :
10.4049/jimmunol.163.1.278 .
PMID
10384126 .
Berryman M, Bretscher A (2000).
"Identification of a Novel Member of the Chloride Intracellular Channel Gene Family (CLIC5) That Associates with the Actin Cytoskeleton of Placental Microvilli" . Mol. Biol. Cell . 11 (5): 1509–21.
doi :
10.1091/mbc.11.5.1509 .
PMC
14863 .
PMID
10793131 .
Tonini R, Ferroni A, Valenzuela SM, et al. (2000).
"Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells" . FASEB J . 14 (9): 1171–8.
doi :
10.1096/fasebj.14.9.1171 .
PMID
10834939 .
S2CID
30652670 .
Valenzuela SM, Mazzanti M, Tonini R, et al. (2001).
"The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle" . J. Physiol . 529 (3): 541–52.
doi :
10.1111/j.1469-7793.2000.00541.x .
PMC
2270212 .
PMID
11195932 .
Harrop SJ, DeMaere MZ, Fairlie WD, et al. (2002).
"Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution" . J. Biol. Chem . 276 (48): 44993–5000.
doi :
10.1074/jbc.M107804200 .
PMID
11551966 .
Warton K, Tonini R, Fairlie WD, et al. (2002).
"Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1" . J. Biol. Chem . 277 (29): 26003–11.
doi :
10.1074/jbc.M203666200 .
PMID
11978800 .
Shanks RA, Larocca MC, Berryman M, et al. (2002).
"AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member" . J. Biol. Chem . 277 (43): 40973–80.
doi :
10.1074/jbc.M112277200 .
PMID
12163479 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Fan L, Yu W, Zhu X (2003).
"Interaction of Sedlin with chloride intracellular channel proteins" . FEBS Lett . 540 (1–3): 77–80.
doi :
10.1016/S0014-5793(03)00228-X .
PMID
12681486 .
S2CID
8573651 .
Mungall AJ, Palmer SA, Sims SK, et al. (2003).
"The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11.
Bibcode :
2003Natur.425..805M .
doi :
10.1038/nature02055 .
PMID
14574404 .
Littler DR, Harrop SJ, Fairlie WD, et al. (2004).
"The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition" . J. Biol. Chem . 279 (10): 9298–305.
doi :
10.1074/jbc.M308444200 .
PMID
14613939 .
Singh H, Cousin MA, Ashley RH (2007). "Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin". FEBS J . 274 (24): 6306–6316.
doi :
10.1111/j.1742-4658.2007.06145.x .
PMID
18028448 .
S2CID
22494250 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
PDB gallery
1k0m : Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms
1k0n : Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione
1k0o : Crystal structure of a soluble form of CLIC1. An intracellular chloride ion channel
1rk4 : Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1