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Chemical compound
Phenyltoloxamine is an
antihistamine with
sedative and
analgesic effects.
[1]
[2] It is available in combination with other drugs such as
paracetamol (acetominophen).
[3]
Common use
Phenyltoloxamine is widely used in preparations as an enhancing
agent for some analgesics and antitussives (
acetaminophen ,
dihydrocodeine ,
codeine ,
hydrocodone ). It is widely used in certain parts of the world as
cough suppressant usually with codeine, and sometimes by itself or in addition to
dextromethorphan as it, like
diphenhydramine , possesses antitussive action of its own and is particularly useful in semi-productive coughs because of its moderate drying action.
Phenyltoloxamine is used in combination with
paracetamol ,
aspirin and other
salicylates and other drugs in proprietary preparations available over the counter for backache, muscle strains and similar conditions.
Adverse effects
Common
adverse effects are those associated with most anticholinergics, with effects being more pronounced in children and the elderly.[
medical citation needed ]
Availability
Though it is rare in several
Western countries [
which? ] , phenyltoloxamine is widely used on the global scale, particularly in the
developing world .
In the past it was not a
controlled substance . It was taken off the market but is available OTC again in the US by some[
which? ] pharmaceutical companies. Some preparations contain opiates such as codeine or hydrocodone and are controlled. When used in preparations with
acetaminophen it is generally
over the counter .
Phenyltoloxamine combinations are sold under wide variety of preparations, brand names and dosages around the world:
Aceta-Gesic, Ed-Flex, Dologesic, Duraxin, Flextra-650, Novagesic, Pain-gesic, Phenylgesic - North America
Codipront - Europe/South America
Codivis - Israel
See also
References
Psychedelics (
5-HT2A agonists)
Benzofurans
Lyserg‐ amides
Phenethyl‐ amines
2C-x
25x -NBx
25x -
NB 25x -
NB3OMe 25x -
NB4OMe 25x -
NBF 25x -
NBMD 25x -
NBOH 25x -
NBOMe Atypical structures
25x -NMx
N-(2C)-fentanyl
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5-Bromo-DMT
5-MeO-2,N ,N -TMT
5-MeO-4,N ,N -TMT
5-MeO-α,N,N-TMT
5-MeO-DMT
5-N ,N -TMT
7,N,N-TMT
α,N,N-TMT
(Bufotenin) 5-HO-DMT
DMT
Norbaeocystin
(Psilocin) 4-HO-DMT
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x -
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MiPT Others
Others
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H1
Agonists Antagonists
Others:
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Phenylpiperazine
antidepressants (e.g.,
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Tetracyclic antidepressants (e.g.,
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iprindole ,
lofepramine ,
nortriptyline ,
protriptyline ,
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H2
H3
H4
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Agonists
Antagonists
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doxylamine ,
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AQ-RA 741
Atropine
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Atypical antipsychotics (e.g.,
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+fluoxetine ),
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Benactyzine
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BIBN 99
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CAR-226,086
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pFHHSiD
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Tridihexethyl
Trihexyphenidyl
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Typical antipsychotics (e.g.,
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Umeclidinium bromide (
+vilanterol )
WIN-2299
Xanomeline
Zamifenacin
Precursors (and
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