From Wikipedia, the free encyclopedia
Sodium salicylate
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Names
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Preferred IUPAC name
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Other names
Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin
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Identifiers
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ChEMBL
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ChemSpider
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DrugBank
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ECHA InfoCard
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100.000.181
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EC Number
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KEGG
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RTECS number
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UNII
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InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1 YKey: ABBQHOQBGMUPJH-UHFFFAOYSA-M YInChI=1/C7H6O3.Na/c8-6-4-2-1- 3-5(6)7(9)10;/h1-4,8H,(H,9,10); /q;+1/p-1/fC7H5O3.Na/q-1;m InChI=1/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1 Key: ABBQHOQBGMUPJH-REWHXWOFAO
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Properties
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C7H5NaO3
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Molar mass
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160.104 g/mol
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Appearance
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White crystals
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Melting point
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200 °C (392 °F; 473 K)
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25.08 g/100 g (-1.5 °C) 107.9 g/100 g (15 °C) 124.6 g/100 g (25 °C) 141.8 g/100 g (78.5 °C) 179 g/100 g (114 °C)
[1]
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Solubility
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Soluble in
glycerol,
1,4-Dioxane,
alcohol
[1]
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Solubility in
methanol
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26.28 g/100 g (15 °C) 34.73 g/100 g (67.2 °C)
[1]
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Pharmacology
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N02BA04 (
WHO)
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Hazards
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Occupational safety and health (OHS/OSH):
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Main hazards
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Harmful
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Eye hazards
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Irritant
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GHS labelling:
[3]
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Warning
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H314,
H331,
H400
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P210,
P261,
P273,
P280,
P305+P351+P338,
P310
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NFPA 704 (fire diamond)
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250 °C (482 °F; 523 K)
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Lethal dose or concentration (LD, LC):
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930 mg/kg (rats, oral)
[2]
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Sodium salicylate is a
sodium salt of
salicylic acid. It can be prepared from
sodium phenolate and
carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing
methyl salicylate (
wintergreen oil) with an excess of
sodium hydroxide.
[4]
Properties
Sodium salicylate is of the
salicylate family.
Uses
It is used in medicine as an
analgesic and
antipyretic. Sodium salicylate also acts as
non-steroidal anti-inflammatory drug (NSAID), and induces
apoptosis in cancer cells
[5]
[6]
[7] and also
necrosis.
[8] It is also a potential replacement for
aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.
[9]
References
- ^
a
b
c
"sodium salicylate". chemister.ru. Retrieved 8 April 2018.
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^ Chambers, Michael.
"ChemIDplus - 54-21-7 - ABBQHOQBGMUPJH-UHFFFAOYSA-M - Sodium salicylate [USP:JAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information". chem.sis.nlm.nih.gov. Retrieved 8 April 2018.
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^
Sigma-Aldrich Co.,
Sodium salicylate. Retrieved on 2014-05-26.
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^ Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009
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^ Klampfer, Lidija; Jörg Cammenga; Hans-Georg Wisniewski; Stephen D. Nimer (1999-04-01). "Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines". Blood. 93 (7): 2386–94.
doi:
10.1182/blood.V93.7.2386.
PMID
10090950.
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^ Rae, Colin; Susana Langa; Steven J. Tucker; David J. MacEwan (2007-07-31).
"Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis". Proceedings of the National Academy of Sciences of the USA. 104 (31): 12790–5.
Bibcode:
2007PNAS..10412790R.
doi:
10.1073/pnas.0701437104.
PMC
1937545.
PMID
17646662.
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^ Stark, Lesley A.; et al. (May 2007).
"Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer". Carcinogenesis. 28 (5): 968–76.
doi:
10.1093/carcin/bgl220.
PMID
17132819.
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^ Schwenger, Paul; Edward Y. Skolnik; Jan Vilcek (1996-04-05).
"Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate". The Journal of Biological Chemistry. 271 (14): 8089–94.
doi:
10.1074/jbc.271.14.8089.
PMID
8626494.
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^ Samson, James.
"Vacuum Ultraviolet Spectroscopy" (PDF). Pied Publications. Archived from
the original (PDF) on October 16, 2006. Retrieved July 26, 2012.
External links
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Inorganic | Halides | |
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Chalcogenides | |
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Pnictogenides | |
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Oxyhalides | |
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Oxychalcogenides | |
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Oxypnictogenides | |
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Others | |
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Organic | |
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Receptor (
ligands) |
DP (D2)Tooltip Prostaglandin D2 receptor |
DP1Tooltip Prostaglandin D2 receptor 1 | |
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DP2Tooltip Prostaglandin D2 receptor 2 | |
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EP (E2)Tooltip Prostaglandin E2 receptor |
EP1Tooltip Prostaglandin EP1 receptor | |
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EP2Tooltip Prostaglandin EP2 receptor | |
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EP3Tooltip Prostaglandin EP3 receptor | |
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EP4Tooltip Prostaglandin EP4 receptor | |
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Unsorted | |
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FP (F2α)Tooltip Prostaglandin F receptor | |
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IP (I2)Tooltip Prostacyclin receptor | |
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TP (TXA2)Tooltip Thromboxane receptor | |
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Unsorted | |
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Enzyme (
inhibitors) |
COX (
PTGS) | |
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PGD2STooltip Prostaglandin D synthase | |
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PGESTooltip Prostaglandin E synthase | |
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PGFSTooltip Prostaglandin F synthase | |
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PGI2STooltip Prostacyclin synthase | |
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TXASTooltip Thromboxane A synthase | |
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Others | |
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