Benorilate (
INN), or benorylate, is an
ester-linked
codrug of
aspirin with
paracetamol. It is used as an
anti-inflammatory and
antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about
Reye syndrome.[1]
Synthesis
Acetyl salicoyl chloride (1) is reacted with paracetamol (2) to give benorilate (3).[2][3][4][5]
^Similä S, Keinänen S, Kouvalainen K (December 1975). "Oral antipyretic therapy: evaluation of benorylate, an ester of acetylsalicylic acid and paracetamol". European Journal of Pediatrics. 121 (1): 15–20.
doi:
10.1007/bf00464391.
PMID2478.
S2CID21112438.
^Mario Portelli & Giorgio Renzi, DE 2402231 (1974 to Whitefin Holding SA)
^Huang Xiaocheng, et al. CN 111056968 (2020 to Guangxi University of Science and Technology)
^Moerk Nielsen, N., Bundgaard, H. (March 1989). "Evaluation of glycolamide esters and various other esters of aspirin as true aspirin prodrugs". Journal of Medicinal Chemistry. 32 (3): 727–734.
doi:
10.1021/jm00123a040.
PMID2918521.