From Wikipedia, the free encyclopedia
Dimaprit
Names
Preferred IUPAC name
3-(Dimethylamino)propyl carbamimidothioate
Other names
3-dimethylaminopropyl sulfanylmethanimidamide
Identifiers
ChEMBL
ChemSpider
KEGG
UNII
InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8)
N Key: OLHQOJYVQUNWPL-UHFFFAOYSA-N
N InChI=1/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8)
Key: OLHQOJYVQUNWPL-UHFFFAOYAQ
Properties
C6 H15 N3 S
Molar mass
161.2684 g/mol
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Dimaprit is a
histamine analog working as a selective
H2 histamine receptor
agonist .
[1]
[2]
[3]
References
^ Kartzung, Betram G.; Trevor, Anthony J., eds. (2014). Basic and Clinical Pharmacology (13th ed.). New York: McGraw-Hill Education. p. 364.
ISBN
978-0071825054 .
^ Kohno, S; Ogawa, K; Nabe, T; Yamamura, H; Ohata, K (May 1993).
"Dimaprit, a Histamine H2 -agonist, Inhibits Anaphylactic Histamine Release from Mast Cells and the Decreased Release is Restored by Thioperamide (H3 -antagonist), but not by Cimetidine (H2 -antagonist)" . Japanese Journal of Pharmacology . 62 (1): 75–9.
doi :
10.1254/jjp.62.75 .
PMID
7688057 .
^ Nakamura, T; Ueno, Y; Goda, Y; Nakamura, A; Shinjo, K; Nagahisa, A (March 1997). "Efficacy of a Selective Histamine H2 Receptor Agonist, Dimaprit, in Experimental Models of Endotoxin Shock and Hepatitis in Mice". European Journal of Pharmacology . 322 (1): 83–89.
doi :
10.1016/S0014-2999(96)00987-9 .
PMID
9088875 .
H1
Agonists Antagonists
Others:
Atypical antipsychotics (e.g.,
aripiprazole ,
asenapine ,
brexpiprazole ,
brilaroxazine ,
clozapine ,
iloperidone ,
olanzapine ,
paliperidone ,
quetiapine ,
risperidone ,
ziprasidone ,
zotepine )
Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone ,
nefazodone ,
trazodone ,
triazoledione )
Tetracyclic antidepressants (e.g.,
amoxapine ,
loxapine ,
maprotiline ,
mianserin ,
mirtazapine ,
oxaprotiline )
Tricyclic antidepressants (e.g.,
amitriptyline ,
butriptyline ,
clomipramine ,
desipramine ,
dosulepin (dothiepin) ,
doxepin ,
imipramine ,
iprindole ,
lofepramine ,
nortriptyline ,
protriptyline ,
trimipramine )
Typical antipsychotics (e.g.,
chlorpromazine ,
flupenthixol ,
fluphenazine ,
loxapine ,
perphenazine ,
prochlorperazine ,
thioridazine ,
thiothixene )
H2
H3
H4