JWH-120 is a synthetic cannabimimetic that was discovered by
John W. Huffman. It is the N-propyl analog of
JWH-122. It is a potent and selective ligand for the
CB2 receptor, but a weaker ligand for the
CB1 receptor. It has a binding affinity of Ki = 6.1 ± 0.7 nM at the CB2 subtype and 173 times selectivity over the CB1 subtype.[1]
^Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, et al. (January 2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists". Bioorganic & Medicinal Chemistry. 13 (1): 89–112.
doi:
10.1016/j.bmc.2004.09.050.
PMID15582455.