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Chemical compound
5F-ADB-PINACA
Legal status
N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H -indazole-3-carboxamide
CAS Number
PubChem
CID
ChemSpider
UNII
CompTox Dashboard (
EPA )
Formula C 19 H 27 F N 4 O 2
Molar mass 362.449 g·mol−1 3D model (
JSmol )
CC(C)(C)[C@@H](C(=O)N)NC(=O)c1c2ccccc2n(n1)CCCCCF
InChI=1S/C19H27FN4O2/c1-19(2,3)16(17(21)25)22-18(26)15-13-9-5-6-10-14(13)24(23-15)12-8-4-7-11-20/h5-6,9-10,16H,4,7-8,11-12H2,1-3H3,(H2,21,25)(H,22,26)/t16-/m1/s1
Key:SOYDDJYBRCNNIT-MRXNPFEDSA-N
5F-ADB-PINACA is a
cannabinoid
designer drug that is an ingredient in some
synthetic cannabis products. It is a potent
agonist of the
CB1 receptor and
CB2 receptor with
EC50 values of 0.24 nM and 2.1 nM respectively.
[1]
[2]
Metabolism
Twelve 5F-ADB-PINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic reactions included oxidative defluorination followed by carboxylation.
[3]
Legality
5F-ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.
[4]
See also
References
^ Banister SD, Moir M, Stuart J, Kevin RC, Wood KE, Longworth M, et al. (September 2015). "Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA". ACS Chemical Neuroscience . 6 (9): 1546–59.
doi :
10.1021/acschemneuro.5b00112 .
PMID
26134475 .
^
"5F-ADB-PINACA" . Cayman Chemical.
^ Carlier J, Diao X, Scheidweiler KB, Huestis MA (May 2017).
"Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry" . Clinical Chemistry . 63 (5): 1008–1021.
doi :
10.1373/clinchem.2016.267575 .
PMID
28302730 .
^
"CNB NEWS RELEASE" . Central Narcotics Bureau (CNB). 30 April 2015. Archived from
the original on 15 July 2015. Retrieved 24 July 2015 .
Phytocannabinoids (
comparison )
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Synthetic cannabinoid receptor agonists / neocannabinoids
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Allosteric
CBR Tooltip Cannabinoid receptor
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Anticannabinoids (antagonists/inverse agonists/antibodies)