From Wikipedia, the free encyclopedia
α-Methylhistamine
Names
IUPAC name
1-(3H -Imidazol-4-yl)propan-2-amine
Systematic IUPAC name
1-(1
H -Imidazol-4-yl)propan-2-amine
[1]
Identifiers
ChEBI
ChEMBL
ChemSpider
MeSH
Alpha-methylhistamine
InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)
Y Key: XNQIOISZPFVUFG-UHFFFAOYSA-N
Y InChI=1/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)
Key: XNQIOISZPFVUFG-UHFFFAOYAW
Properties
C 6 H 11 N 3
Molar mass
125.175 g·mol−1
log P
-0.346
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
α-Methylhistamine is a
histamine agonist selective for the receptor subtype
H3 . It causes lowering of blood pressure and a decrease of
heart rate in animal models.
[2]
References
H1
Agonists Antagonists
Others:
Atypical antipsychotics (e.g.,
aripiprazole ,
asenapine ,
brexpiprazole ,
brilaroxazine ,
clozapine ,
iloperidone ,
olanzapine ,
paliperidone ,
quetiapine ,
risperidone ,
ziprasidone ,
zotepine )
Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone ,
nefazodone ,
trazodone ,
triazoledione )
Tetracyclic antidepressants (e.g.,
amoxapine ,
loxapine ,
maprotiline ,
mianserin ,
mirtazapine ,
oxaprotiline )
Tricyclic antidepressants (e.g.,
amitriptyline ,
butriptyline ,
clomipramine ,
desipramine ,
dosulepin (dothiepin) ,
doxepin ,
imipramine ,
iprindole ,
lofepramine ,
nortriptyline ,
protriptyline ,
trimipramine )
Typical antipsychotics (e.g.,
chlorpromazine ,
flupenthixol ,
fluphenazine ,
loxapine ,
perphenazine ,
prochlorperazine ,
thioridazine ,
thiothixene )
H2
H3
H4