JNJ-5207852 is a
histamine antagonist selective for the
H3 subtype. It has
stimulant and
nootropic effects in animal studies,[1] and has been suggested as a possible treatment for some memory defects associated with
epilepsy.[2] JNJ-5207852 itself did not progress to clinical development due to poor pharmacokinetic characteristics, but the related compound
JNJ-17216498 was in a Phase II clinical trial for the treatment of
narcolepsy in 2007.[3]
^Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E, Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K (Mar 2006). "Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice". Neuropharmacology. 50 (4): 404–11.
doi:
10.1016/j.neuropharm.2005.09.017.
PMID16310812.
S2CID39844562.