JWH-307 is an
analgesic drug used in scientific research, which acts as a
cannabinoid agonist at both the
CB1 and
CB2receptors. It is somewhat selective for the CB2 subtype, with a
Ki of 7.7 nM at CB1 vs 3.3 nM at CB2.[1] It was discovered by, and named after,
John W. Huffman. JWH-307 was detected as an ingredient in
synthetic cannabis smoking blends in 2012, initially in Germany.[2][3]
^Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorganic & Medicinal Chemistry Letters 2006; 16:5432-5435.
^Ernst L, Krüger K, Lindigkeit R, Schiebel HM, Beuerle T (October 2012). "Synthetic cannabinoids in "spice-like" herbal blends: first appearance of JWH-307 and recurrence of JWH-018 on the German market". Forensic Science International. 222 (1–3): 216–22.
doi:
10.1016/j.forsciint.2012.05.027.
PMID22748479.
^Kneisel S, Auwärter V (July 2012). "Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction". Journal of Mass Spectrometry. 47 (7): 825–35.
Bibcode:
2012JMSp...47..825K.
doi:
10.1002/jms.3020.
PMID22791249.