Norpipanone (
INN,
BAN; Hexalgon) is an
opioidanalgesic related to
methadone which was developed in
Germany and distributed in
Hungary,
Argentina, and other countries.[2][3] It had originally not been under
international control but upon observation of
case reports of
addiction it was reviewed and shortly thereafter became a
controlled substance.[2][3] In the United States, it is a Schedule I controlled substance (ACSCN 9636, zero annual manufacturing quota as of 2014). The salts in use are the hydrobromide (free base conversion ratio 0.806) and hydrochloride (0.902).
^Dupré DJ, Elks J, Hems BA, Speyer KN, Evans RM (1949). "113. Analgesics. Part I. Esters and ketones derived from α-amino-ω-cyano-ωωdiarylalkanes". Journal of the Chemical Society (Resumed).
Chemical Society: 500–510.
doi:
10.1039/JR9490000500.
^Bockmühl M, Ehrhart G (1949). "Über eine neue Klasse von spasmolytisch und analgetisch wirkenden Verbindungen, I". Justus Liebigs Annalen der Chemie. 561: 52–86.
doi:
10.1002/jlac.19495610107.