From Wikipedia, the free encyclopedia
Iodophenpropit
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Names
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IUPAC name
3-(1H-imidazol-5-yl)propyl N'-[2-(4-iodophenyl)ethyl]imidothiocarbamate
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Other names
1-[3-(3H-imidazol-4-yl)propylthio]-N'-[2-(4-iodophenyl)ethyl]formamidine
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Identifiers
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ChEMBL
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ChemSpider
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MeSH
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Iodophenpropit
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UNII
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C1=CC(=CC=C1CCN=C(N)SCCCC2=CN=CN2)I
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Properties
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C15H19IN4S
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Molar mass
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414.30763 g/mol
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Iodophenpropit is a
histamine antagonist which binds selectively to the
H3 subtype. Its 125I
radiolabelled form has been used for mapping the distribution of H3 receptors in animal studies.
[1]
[2]
References
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^ Jansen, FP; Wu, TS; Voss, HP; Steinbusch, HW; Vollinga, RC; Rademaker, B; Bast, A; Timmerman, H (1994).
"Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain".
British Journal of Pharmacology. 113 (2): 355–62.
doi:
10.1111/j.1476-5381.1994.tb16995.x.
PMC
1510107.
PMID
7834183.
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^ Jansen, FP; Mochizuki, T; Maeyama, K; Leurs, R; Timmerman, H (2000). "Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit". Naunyn-Schmiedeberg's Archives of Pharmacology. 362 (1): 60–7.
doi:
10.1007/s002100000227.
PMID
10935534.
S2CID
21293180.
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H1 | Agonists | |
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Antagonists |
- Others:
Atypical antipsychotics (e.g.,
aripiprazole,
asenapine,
brexpiprazole,
brilaroxazine,
clozapine,
iloperidone,
olanzapine,
paliperidone,
quetiapine,
risperidone,
ziprasidone,
zotepine)
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Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone,
nefazodone,
trazodone,
triazoledione)
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Tetracyclic antidepressants (e.g.,
amoxapine,
loxapine,
maprotiline,
mianserin,
mirtazapine,
oxaprotiline)
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Tricyclic antidepressants (e.g.,
amitriptyline,
butriptyline,
clomipramine,
desipramine,
dosulepin (dothiepin),
doxepin,
imipramine,
iprindole,
lofepramine,
nortriptyline,
protriptyline,
trimipramine)
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Typical antipsychotics (e.g.,
chlorpromazine,
flupenthixol,
fluphenazine,
loxapine,
perphenazine,
prochlorperazine,
thioridazine,
thiothixene)
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H2 | |
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H3 | |
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H4 | |
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