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Chemical compound
Fenpiverinium
ATC code
1-(4-Amino-4-oxo-3,3-diphenylbutyl)-1-methylpiperidinium
CAS Number
PubChem
CID
ChemSpider
UNII
CompTox Dashboard (
EPA )
Formula C 22 H 29 N 2 O +
Molar mass 337.487 g·mol−1 3D model (
JSmol )
C[N+]1(CCCCC1)CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N
InChI=1S/C22H28N2O/c1-24(16-9-4-10-17-24)18-15-22(21(23)25,19-11-5-2-6-12-19)20-13-7-3-8-14-20/h2-3,5-8,11-14H,4,9-10,15-18H2,1H3,(H-,23,25)/p+1
Key:QDIYJDPBMZUZEH-UHFFFAOYSA-O
(verify)
Fenpiverinium is an
anticholinergic and
antispasmodic compound;
[1] it is marketed as a
combination drug with
pitofenone hydrochloride and either
nimesulide or
metamizole in Eastern Europe and India to treat smooth muscle spasms and pain.
[2]
The combination with metamizole was removed from the market in Lithuania for safety reasons in 2000
[3] and a boxed warning against use by children and adolescents was added in Serbia in 2005.
[4] In 2016 India banned marketing of the combination with nimesulide along with 344 other combination drugs;
[5]
[6] the order was overturned in December and appealed by the Government in January 2017.
[7]
References
^
"Proposed INNs List 26" (PDF) . WHO Chronicle . 25 (9). 1971. .
"Recommended INNs List 12" (PDF) . WHO Chronicle . 26 (10). 1973.
^ Vardanyan R (2017).
Piperidine-Based Drug Discovery . Elsevier.
ISBN
9780128134283 .
^
Consolidated List of Products - Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or Not Approved by Governments, Twelfth Issue . WHO. 2005. p. 305. Archived from
the original on November 8, 2014.
^
Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments, Fourteenth Issue . WHO. 2009. p. 35. [
dead link ]
^
"Health ministry bans 344 fixed dose combination drugs" . The Times of India . March 14, 2016.
^
"Gazette of India D. L.-33004/99. PART II—Section 3—Sub-section (ii)" (PDF) . Government of India. March 10, 2016. Archived from
the original (PDF) on 2018-08-26. Retrieved 2017-06-22 .
^
"Govt moves SC to enforce ban on 344 Fixed Dose Combination drugs" . The Times of India . January 31, 2017.
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