From Wikipedia, the free encyclopedia
Chemical compound
Trendione
Other names RU-2065; Trenavar; Triendione; Estra-4,9,11-triene-3,17-dione
Drug class
Androgen ;
Anabolic steroid ;
Progestogen
(8S ,13S ,14S )-13-Methyl-1,2,6,7,8,14,15,16-octahydrocyclopenta[a ]phenanthrene-3,17-dione
CAS Number
PubChem
CID
ChemSpider
UNII
CompTox Dashboard (
EPA )
Formula C 18 H 20 O 2
Molar mass 268.356 g·mol−1 3D model (
JSmol )
C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CCC2=O
InChI=1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-16H,2-7H2,1H3/t15-,16+,18+/m1/s1
Key:KBSXJBBFQODDTQ-RYRKJORJSA-N
Trendione (developmental code name RU-2065 ; nickname Trenavar ), also known as estra-4,9,11-triene-3,17-dione , is an
androgen prohormone as well as
metabolite of the
anabolic steroid
trenbolone .
[1]
[2]
[3]
[4]
[5] Trendione is to trenbolone as
androstenedione is to
testosterone .
[6] The compound is inactive itself, showing more than 100-fold lower
affinity for the
androgen and
progesterone receptors than trenbolone.
[7]
[8] It is a
designer steroid and has been sold on the internet as a "
nutritional supplement ".
[1] Trendione is listed in the
United States
Designer Anabolic Steroid Control Act of 2014 .
[1]
See also
References
^
a
b
c Liane BJ, Magee C (October 2016).
"Guerilla Warfare on the Pancreas? A Case of Acute Pancreatitis From a Supplement Known to Contain Anabolic-Androgenic Steroids" . Mil Med . 181 (10): e1395–e1397.
doi :
10.7205/MILMED-D-15-00575 .
PMID
27753588 .
^ Yarrow JF, McCoy SC, Borst SE (June 2010). "Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity". Steroids . 75 (6): 377–89.
doi :
10.1016/j.steroids.2010.01.019 .
PMID
20138077 .
S2CID
205253265 .
^ Metzler M (April 1989). "Metabolism of some anabolic agents: toxicological and analytical aspects". J. Chromatogr . 489 (1): 11–21.
doi :
10.1016/s0378-4347(00)82880-7 .
PMID
2745641 .
^ Yarrow JF, Conover CF, McCoy SC, Lipinska JA, Santillana CA, Hance JM, Cannady DF, VanPelt TD, Sanchez J, Conrad BP, Pingel JE, Wronski TJ, Borst SE (April 2011).
"17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate" . Am. J. Physiol. Endocrinol. Metab . 300 (4): E650–60.
doi :
10.1152/ajpendo.00440.2010 .
PMC
6189634 .
PMID
21266670 .
^ Spranger B, Metzler M (April 1991). "Disposition of 17 beta-trenbolone in humans". J. Chromatogr . 564 (2): 485–92.
doi :
10.1016/0378-4347(91)80517-g .
PMID
1874853 .
^
Advances in Agronomy . Elsevier. 13 April 2007. pp. 16–.
ISBN
978-0-08-048819-6 .
^ Bauer ER, Daxenberger A, Petri T, Sauerwein H, Meyer HH (December 2000). "Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor". APMIS . 108 (12): 838–46.
doi :
10.1111/j.1600-0463.2000.tb00007.x .
PMID
11252818 .
S2CID
22776408 .
^ Delettré J, Mornon JP, Lepicard G, Ojasoo T, Raynaud JP (January 1980). "Steroid flexibility and receptor specificity". J. Steroid Biochem . 13 (1): 45–59.
doi :
10.1016/0022-4731(80)90112-0 .
PMID
7382482 .
AR Tooltip Androgen receptor
Agonists
SARMs Tooltip Selective androgen receptor modulator Antagonists
GPRC6A
PR Tooltip Progesterone receptor
Agonists
Testosterone derivatives: Progestins:
6,6-Difluoronorethisterone
6,6-Difluoronorethisterone acetate
17α-Allyl-19-nortestosterone
Allylestrenol
Altrenogest
Chloroethynylnorgestrel
Cingestol
Danazol
Desogestrel
Dienogest
Ethinylandrostenediol
Ethisterone
Ethynerone
Etonogestrel
Etynodiol
Etynodiol diacetate
Gestodene
Gestrinone
Levonorgestrel
Levonorgestrel esters (e.g.,
levonorgestrel butanoate )
Lynestrenol
Lynestrenol phenylpropionate
Metynodiol
Metynodiol diacetate
Norelgestromin
Norethisterone (norethindrone)
Norethisterone esters (e.g.,
norethisterone acetate ,
norethisterone enanthate )
Noretynodrel
Norgesterone
Norgestimate
Norgestrel
Norgestrienone
Norvinisterone
Oxendolone
Quingestanol
Quingestanol acetate
Tibolone
Tigestol
Tosagestin ; Anabolic–androgenic steroids:
11β-Methyl-19-nortestosterone
11β-Methyl-19-nortestosterone dodecylcarbonate
19-Nor-5-androstenediol
19-Nor-5-androstenedione
19-Nordehydroepiandrosterone
Bolandiol
Bolandiol dipropionate
Bolandione
Dimethisterone
Dienedione
Dienolone
Dimethandrolone
Dimethandrolone buciclate
Dimethandrolone dodecylcarbonate
Dimethandrolone undecanoate
Dimethyldienolone
Dimethyltrienolone
Ethyldienolone
Ethylestrenol (ethylnandrol)
Methyldienolone
Metribolone (R-1881)
Methoxydienone (methoxygonadiene)
Mibolerone
Nandrolone
Nandrolone esters (e.g.,
nandrolone decanoate ,
nandrolone phenylpropionate )
Norethandrolone
Normethandrone (methylestrenolone, normethandrolone, normethisterone)
RU-2309
Tetrahydrogestrinone
Trenbolone (trienolone)
Trenbolone esters (e.g.,
trenbolone acetate ,
trenbolone enanthate )
Trendione
Trestolone
Trestolone acetate
Mixed (
SPRMs Tooltip Selective progesterone receptor modulators ) Antagonists
mPR Tooltip Membrane progesterone receptor (
PAQR Tooltip Progestin and adipoQ receptor )