Inocoterone acetate was investigated for the treatment of
acne but showed only modest (albeit
statistically significant)
efficacy in
clinical trials.[2][5][6] A reduction of 26% of lesions was observed in males treated with the drug after 16 weeks (~3.7 months).[6][1] However, this is notably far less than that achieved with other agents such as
benzoyl peroxide or
antibiotics, which produce 50–75% reductions within 2 months.[1] Similar poor results with the topical route have disappointingly been found for other antiandrogens, such as
cyproterone acetate and
spironolactone.[1] Similarly to
rosterolone, inocoterone acetate has no systemic antiandrogenic activity when applied systemically.[7]
^
abcdBoettger RF, Fukushima LH (2006).
"Common skin disorders". In Helms RA, Quan DJ (eds.). Textbook of Therapeutics: Drug and Disease Management. Lippincott Williams & Wilkins. pp. 203–256 (211).
ISBN978-0-7817-5734-8.
^
abLookingbill DP, Abrams BB, Ellis CN, Jegasothy BV, Lucky AW, Ortiz-Ferrer LC, et al. (September 1992). "Inocoterone and acne. The effect of a topical antiandrogen: results of a multicenter clinical trial". Archives of Dermatology. 128 (9): 1197–1200.
doi:
10.1001/archderm.128.9.1197.
PMID1387778.
^Neumann F, Töpert M (1990). "Antiandrogens and Hair Growth: Basic Concepts and Experimental Research". In Orfanos CE, Happle R (eds.). Hair and Hair Diseases. pp. 791–826.
doi:
10.1007/978-3-642-74612-3_34.
ISBN978-3-642-74614-7.