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abcSouness GW, Morris DJ (March 1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat". Hypertension. 27 (3 Pt 1): 421–425.
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^Lerner LJ (1975). "Androgen antagonists". Pharmacology & Therapeutics B. 1 (2): 217–231.
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PMID772705. 11α Hydroxyprogesterone, while devoid of androgenic, estrogenic and progestational activity, is weakly anti androgenic in castrate rats.
^Nguyen KT, Virus C, Günnewich N, Hannemann F, Bernhardt R (May 2012). "Changing the regioselectivity of a P450 from C15 to C11 hydroxylation of progesterone". ChemBioChem. 13 (8): 1161–1166.
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S2CID34483686. 11α-Hydroxyprogesterone is an important pharmaceutical compound with anti-androgenic and blood-pressure-regulating activity. [...] 11α-Hydroxyprogesterone can therefore influence blood pressure regulation.12 Furthermore, 11α-hydroxyprogesterone exhibits an anti-androgenic activity with minimal estrogenic and progestational side effects.13 This substance has been proposed for treating skin diseases, especially for psoriasis in combination with clobetasol propionate and minoxidil.14.
^Millikan LE (19 April 2016).
Drug Therapy in Dermatology. CRC Press. p. 403.
ISBN978-0-203-90831-0. Topical antiandrogens have also been tried, including topical progesterone, which proved ineffective. However, small studies with topical 11α-hydroxyprogesterone and 17α-estradiol showed some benefit [38,39].
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