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Chemical compound
Aglepristone
Trade names Alizin Other names RU-46534; RU-534; 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17α-[(Z)-propenyl]estra-4,9-dien-3-one
Drug class
Antiprogestogen ;
Antiglucocorticoid
ATC code
(8S ,11R ,13S ,14S ,17R )-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z )-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a ]phenanthren-3-one
CAS Number
PubChem
CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (
EPA )
ECHA InfoCard
100.211.372
Formula C 29 H 37 N O 2
Molar mass 431.620 g·mol−1 3D model (
JSmol )
C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1
Key:RTCKAOKDXNYXEH-FWSJOHTJSA-N
Aglepristone (
INN Tooltip International Nonproprietary Name ) (brand name Alizin ; former developmental code names RU-46534 , RU-534 ) is a
synthetic ,
steroidal
antiprogestogen related to
mifepristone which is marketed by
Virbac in several
European countries for use in
veterinary medicine .
[1]
[2]
[3] It is specifically used as an
abortifacient in
pregnant animals.
[1]
[3]
[4] Aglepristone, similarly to mifepristone, also possesses some
antiglucocorticoid activity.
[5]
[6]
See also
References
^
a
b Kaufman LK, Baldwin CJ (1 December 2013).
"Pregnancy Loss in the Bitch and Queen" . In Bonagura JD, Twedt DC (eds.). Kirk's Current Veterinary Therapy XV . Elsevier Health Sciences. pp. 3009–.
ISBN
978-0-323-22762-9 .
^ Squires EJ (2010).
"Endocrine manipulation of reproduction." . Applied Animal Endocrinology . CABI. pp. 207–.
ISBN
978-1-84593-755-3 .
^
a
b Papich MC (3 November 2010).
"Aglepristone" . Saunders Handbook of Veterinary Drugs: Small and Large Animal . Elsevier Health Sciences. pp. 120–.
ISBN
978-1-4377-0192-0 .
^ Fieni F, Martal J, Marnet PG, Siliart B, Bernard F, Riou M, Bruyas JF, Tainturier D (2001). Concannon PW (ed.). "Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534)". Journal of Reproduction and Fertility. Supplement . Advances in reproduction in dogs, cats and exotic carnivores: proceedings of the fourth International Symposium on Canine and Feline Reproduction, Oslo, Norway, 29 June-1 July 2000. 57 : 243–8.
ISBN
978-0-906545-37-9 .
PMID
11787157 .
^ Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, et al. (October 2011). "Induction of parturition with aglepristone in the Majorera goat". Reproduction in Domestic Animals = Zuchthygiene . 46 (5): 882–888.
doi :
10.1111/j.1439-0531.2011.01759.x .
PMID
21320179 .
^ Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC (March 2008). "Hormonal changes in spontaneous and aglépristone-induced parturition in dogs". Theriogenology . 69 (4): 399–407.
doi :
10.1016/j.theriogenology.2007.10.008 .
PMID
18054071 .
GR Tooltip Glucocorticoid receptor
PR Tooltip Progesterone receptor
Agonists
Testosterone derivatives: Progestins:
6,6-Difluoronorethisterone
6,6-Difluoronorethisterone acetate
17α-Allyl-19-nortestosterone
Allylestrenol
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levonorgestrel butanoate )
Lynestrenol
Lynestrenol phenylpropionate
Metynodiol
Metynodiol diacetate
Norelgestromin
Norethisterone (norethindrone)
Norethisterone esters (e.g.,
norethisterone acetate ,
norethisterone enanthate )
Noretynodrel
Norgesterone
Norgestimate
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19-Nor-5-androstenediol
19-Nor-5-androstenedione
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Bolandiol
Bolandiol dipropionate
Bolandione
Dimethisterone
Dienedione
Dienolone
Dimethandrolone
Dimethandrolone buciclate
Dimethandrolone dodecylcarbonate
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Mibolerone
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Nandrolone esters (e.g.,
nandrolone decanoate ,
nandrolone phenylpropionate )
Norethandrolone
Normethandrone (methylestrenolone, normethandrolone, normethisterone)
RU-2309
Tetrahydrogestrinone
Trenbolone (trienolone)
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trenbolone acetate ,
trenbolone enanthate )
Trendione
Trestolone
Trestolone acetate
Mixed (
SPRMs Tooltip Selective progesterone receptor modulators ) Antagonists
mPR Tooltip Membrane progesterone receptor (
PAQR Tooltip Progestin and adipoQ receptor )