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Chemical compound
4-Hydroxytestosterone
Other names 4,17β-Dihydroxyandrost-4-en-3-one; Androst-4-ene-4,17β-diol-3-one; Desmethylenestebol
4,17-Dihydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a ]phenanthren-3-one
CAS Number
PubChem
CID
DrugBank
ChemSpider
UNII
CompTox Dashboard (
EPA )
Formula C 19 H 28 O 3
Molar mass 304.430 g·mol−1 3D model (
JSmol )
O=C4C(\O)=C2/[C@]([C@H]1CC[C@@]3([C@@H](O)CC[C@H]3[C@@H]1CC2)C)(C)CC4
InChI=1S/C19H28O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,16,21-22H,3-10H2,1-2H3/t11-,12-,13-,16-,18+,19-/m0/s1
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4-Hydroxytestosterone (4-OHT ), also known as 4,17β-dihydroxyandrost-4-en-3-one , is a
synthetic
anabolic-androgenic steroid (AAS) and a
derivative of
testosterone that was never marketed. It was first patented by
G.D. Searle & Company in 1955
[1] and is
testosterone with a hydroxy group at the four position. 4-OHT has moderate
anabolic , mild
androgenic , and
anti-aromatase properties and is similar to the steroid
clostebol (4-chlorotestosterone).
[2]
See also
References
^
US 2762818 , Levy H, Mednick ML, "4-Hydroxytestosterone and esters", issued 11 September 1956, assigned to GD Searle.
^ Kohler M, Parr MK, Opfermann G, Thevis M, Schlörer N, Marner FJ, Schänzer W (March 2007). "Metabolism of 4-hydroxyandrostenedione and 4-hydroxytestosterone: Mass spectrometric identification of urinary metabolites". Steroids . 72 (3): 278–86.
doi :
10.1016/j.steroids.2006.11.018 .
PMID
17207827 .
S2CID
34982808 .
AR Tooltip Androgen receptor
Agonists
SARMs Tooltip Selective androgen receptor modulator Antagonists
GPRC6A