RU-58841 produces
cyanonilutamide (RU-56279) and RU-59416 as
metabolites in animals.[8] Cyanonilutamide has relatively low affinity for the androgen receptor but shows significant
antiandrogenic activity in animals.[8] RU-59416 has very low affinity for the androgen receptor.[8]
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^Van Dort ME, Jung YW (April 2001). "Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands". Bioorganic & Medicinal Chemistry Letters. 11 (8): 1045–1047.
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^Poulos GA, Mirmirani P (February 2005). "Investigational medications in the treatment of alopecia". Expert Opinion on Investigational Drugs. 14 (2): 177–184.
doi:
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PMID15757393.
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^Elancheran R, Maruthanila VL, Ramanathan M, Kabilan S, Devi R, Kunnumakara A, Kotoky J (2015). "Recent discoveries and developments of androgen receptor based therapy for prostate cancer". MedChemComm. 6 (5): 746–768.
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ISSN2040-2503.
S2CID72654573.
^
abcCousty-Berlin D, Bergaud B, Bruyant MC, Battmann T, Branche C, Philibert D (October 1994). "Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: relation of their systemic activity to the formation of a common metabolite". The Journal of Steroid Biochemistry and Molecular Biology. 51 (1–2): 47–55.
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