Vesicular Inhibitory Amino Acid Transporter

SLC32A1
Identifiers
Aliases	SLC32A1, VGAT, VIAAT, solute carrier family 32 member 1
External IDs	OMIM: 616440; MGI: 1194488; HomoloGene: 56451; GeneCards: SLC32A1; OMA: SLC32A1 - orthologs
Gene location ( Human)
Chr.	Chromosome 20 (human)
End	38,729,372 bp
Gene location ( Mouse)
Chr.	Chromosome 2 (mouse)
End	158,457,668 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; putamen; ; prefrontal cortex; ; caudate nucleus; ; endothelial cell; ; external globus pallidus; ; cingulate gyrus; ; anterior cingulate cortex; ; middle temporal gyrus; ; right frontal lobe;
	Top expressed in
	dorsal tegmental nucleus; ; nucleus accumbens; ; nucleus of stria terminalis; ; lateral septal nucleus; ; superior colliculus; ; globus pallidus; ; central gray substance of midbrain; ; medulla oblongata; ; Rostral migratory stream; ; olfactory tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycine transmembrane transporter activity; amino acid transmembrane transporter activity; gamma-aminobutyric acid:proton symporter activity;
Cellular component	integral component of membrane; membrane; synaptic vesicle; plasma membrane; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; synapse; inhibitory synapse; synaptic vesicle membrane; presynaptic active zone; dendrite terminus; dendrite; cone cell pedicle; intracellular organelle; cell tip; neuron projection; neuron projection terminus; cytoplasmic vesicle membrane; cytoplasmic vesicle; integral component of synaptic vesicle membrane; GABA-ergic synapse;
Biological process	amino acid transmembrane transport; human ageing; ion transport; gamma-aminobutyric acid transport; neurotransmitter transport; hippocampus development; neurotransmitter secretion; glycine transport; neurotransmitter loading into synaptic vesicle;
	Sources: Amigo / QuickGO
Orthologs
	140679
	22348
	ENSG00000101438
	ENSMUSG00000037771
	Q9H598
	O35633
	NM_080552
	NM_009508
	NP_542119
	NP_033534
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.^[5]

The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/ polyamine transporter family II.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101438 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037771 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1".

McIntire SL, Reimer RJ, Schuske K, et al. (1997). "Identification and characterization of the vesicular GABA transporter". Nature. 389 (6653): 870–6. doi: 10.1038/39908. PMID 9349821. S2CID 4404823.
Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain". Hum. Genet. 103 (6): 666–73. doi: 10.1007/s004390050889. PMID 9921901. S2CID 23696667.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode: 2001Natur.414..865D. doi: 10.1038/414865a. PMID 11780052.
Chessler SD, Simonson WT, Sweet IR, Hammerle LP (2002). "Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets". Diabetes. 51 (6): 1763–71. doi: 10.2337/diabetes.51.6.1763. PMID 12031963.
Jellali A, Stussi-Garaud C, Gasnier B, et al. (2002). "Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina". J. Comp. Neurol. 449 (1): 76–87. doi: 10.1002/cne.10272. PMID 12115694. S2CID 27646744.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Geigerseder C, Doepner R, Thalhammer A, et al. (2003). "Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors". Neuroendocrinology. 77 (5): 314–23. doi: 10.1159/000070897. hdl: 11336/36231. PMID 12806177. S2CID 7652352.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101438 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037771 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1".

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See also

References

Further reading