Slc25a39

SLC25A39
Identifiers
Aliases	SLC25A39, CGI69, CGI-69, solute carrier family 25 member 39
External IDs	OMIM: 610820; MGI: 1196386; HomoloGene: 69200; GeneCards: SLC25A39; OMA: SLC25A39 - orthologs
Gene location ( Human)
Chr.	Chromosome 17 (human)
End	44,324,870 bp
Gene location ( Mouse)
Chr.	Chromosome 11 (mouse)
End	102,298,772 bp
RNA expression pattern
	Top expressed in
	blood; ; mucosa of transverse colon; ; right lobe of thyroid gland; ; anterior pituitary; ; right testis; ; right adrenal gland; ; left lobe of thyroid gland; ; right adrenal cortex; ; body of pancreas; ; left adrenal cortex;
	Top expressed in
	right kidney; ; yolk sac; ; embryo; ; spermatocyte; ; spermatid; ; lip; ; embryo; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane transporter activity;
Cellular component	membrane; mitochondrion; mitochondrial inner membrane; integral component of membrane;
Biological process	heme biosynthetic process; mitochondrial transport; transmembrane transport;
	Sources: Amigo / QuickGO
Orthologs
	51629
	68066
	ENSG00000013306
	ENSMUSG00000018677
	Q9BZJ4
	Q9D8K8
	NM_001143780; NM_016016; NM_001321240; NM_001321241; NM_001366726
	NM_026542
	NP_001137252; NP_001308169; NP_001308170; NP_057100; NP_001353655
	NP_080818
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 25 member 39 is a protein that in humans is encoded by the SLC25A39 gene.^[5]^[6] The protein has been shown to be necessary for the import of the major antioxidant glutathione into the mitochondria. ^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013306 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018677 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Haitina T, Lindblom J, Renstrom T, Fredriksson R (Nov 2006). "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system". Genomics. 88 (6): 779–90. doi: 10.1016/j.ygeno.2006.06.016. PMID 16949250.
^ "Entrez Gene: SLC25A39 solute carrier family 25, member 39".
^ Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh H, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K (Nov 2021). "SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells". Nature. 599 (7883): 136–140. Bibcode: 2021Natur.599..136W. doi: 10.1038/s41586-021-04025-w. PMC 10981497. PMID 34707288. S2CID 240072540.
^ "Scientists discover how mitochondria import antioxidants". Retrieved January 22, 2022.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi: 10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi: 10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Yu XX, Lewin DA, Zhong A, et al. (2001). "Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69". Biochem. J. 353 (Pt 2): 369–75. doi: 10.1042/0264-6021:3530369. PMC 1221580. PMID 11139402.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi: 10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000013306 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018677 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16949250-5] Haitina T, Lindblom J, Renstrom T, Fredriksson R (Nov 2006). "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system". Genomics. 88 (6): 779–90. doi: 10.1016/j.ygeno.2006.06.016. PMID 16949250.

[entrez-6] "Entrez Gene: SLC25A39 solute carrier family 25, member 39".

[7] Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh H, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K (Nov 2021). "SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells". Nature. 599 (7883): 136–140. Bibcode: 2021Natur.599..136W. doi: 10.1038/s41586-021-04025-w. PMC 10981497. PMID 34707288. S2CID 240072540.

[8] "Scientists discover how mitochondria import antioxidants". Retrieved January 22, 2022.

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See also

References

Further reading