From Wikipedia, the free encyclopedia
Protein found in humans
Zinc transporter ZIP1 is a
protein that in humans is encoded by the SLC39A1
gene .
[5]
[6]
[7]
The protein ZIP1 is responsible for the active transport of
zinc into
prostate cells. In many
prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.
[8]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000143570 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000052310 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics . 62 (2): 272–80.
doi :
10.1006/geno.1999.5993 .
PMID
10610721 .
^ Gaither LA, Eide DJ (Mar 2000).
"Functional expression of the human hZIP2 zinc transporter" . J Biol Chem . 275 (8): 5560–4.
doi :
10.1074/jbc.275.8.5560 .
PMID
10681536 .
^
"Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1" .
^ Costello LC, Franklin RB (2006).
"The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots" . Mol. Cancer . 5 : 17.
doi :
10.1186/1476-4598-5-17 .
PMC
1481516 .
PMID
16700911 .
Further reading
Lai CH, Chou CY, Ch'ang LY, et al. (2000).
"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics" . Genome Res . 10 (5): 703–13.
doi :
10.1101/gr.10.5.703 .
PMC
310876 .
PMID
10810093 .
Gaither LA, Eide DJ (2001).
"The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells" . J. Biol. Chem . 276 (25): 22258–64.
doi :
10.1074/jbc.M101772200 .
PMID
11301334 .
Milon B, Dhermy D, Pountney D, et al. (2001). "Differential subcellular localization of hZip1 in adherent and non-adherent cells". FEBS Lett . 507 (3): 241–6.
doi :
10.1016/S0014-5793(01)02950-7 .
PMID
11696349 .
S2CID
19962909 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Franklin RB, Ma J, Zou J, et al. (2003).
"Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells" . J. Inorg. Biochem . 96 (2–3): 435–42.
doi :
10.1016/S0162-0134(03)00249-6 .
PMC
4465841 .
PMID
12888280 .
Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004).
"Structure, function, and regulation of a subfamily of mouse zinc transporter genes" . J. Biol. Chem . 278 (50): 50142–50.
doi :
10.1074/jbc.M304163200 .
PMID
14525987 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Franklin RB, Feng P, Milon B, et al. (2006).
"hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer" . Mol. Cancer . 4 : 32.
doi :
10.1186/1476-4598-4-32 .
PMC
1243239 .
PMID
16153295 .
Tang Z, Sahu SN, Khadeer MA, et al. (2006). "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone . 38 (2): 181–98.
doi :
10.1016/j.bone.2005.08.010 .
PMID
16203195 .
Otsuki T, Ota T, Nishikawa T, et al. (2007).
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Res . 12 (2): 117–26.
doi :
10.1093/dnares/12.2.117 .
PMID
16303743 .
Huang L, Kirschke CP (2007).
"A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein" . FEBS J . 274 (15): 3986–97.
doi :
10.1111/j.1742-4658.2007.05933.x .
PMID
17635580 .
S2CID
21792127 .
By group
SLC1–10
(1): (2): (3): (4): (5): (6): (7): (8): (9): (10):
SLC11–20
(11): (12): (13): (14): (15): (16): (17): (18): (19): (20):
SLC21–30
(21): (22): (23): (24): (25): (26): (27): (28): (29): (30):
SLC31–40
(31): (32): (33): (34): (35): (36): (37): (38): (39): (40):
SLC41–48
(41): (42): (43): (44): (45): (46): (47): (48):