4F2 cell-surface antigen heavy chain is a
protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2)
gene.[5][6]
SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known as
CD98 (cluster of differentiation 98).[7][8]
Function
SLC3A2 is a member of the
solute carrier family and encodes a cell surface, transmembrane protein with an
alpha-amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]
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