The sodium/glucose cotransporter 2 (SGLT2) is a
protein that in humans is encoded by the SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter))
gene.[5]
Function
SGLT2 is a member of the
sodium glucose cotransporter family, which are sodium-dependent
glucose transport proteins. SGLT2 is the major cotransporter involved in glucose
reabsorption in the kidney.[6] SGLT2 is located in the early
proximal tubule, and is responsible for reabsorption of 80-90% of the glucose filtered by the kidney
glomerulus.[7] Most of the remaining glucose absorption is by
sodium/glucose cotransporter 1 (SGLT1) in more distal sections of the proximal tubule.[8]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wells RG, Mohandas TK, Hediger MA (Sep 1993). "Localization of the Na+/glucose cotransporter gene SGLT2 to human chromosome 16 close to the centromere". Genomics. 17 (3): 787–9.
doi:
10.1006/geno.1993.1411.
PMID8244402.
van den Heuvel LP, Assink K, Willemsen M, Monnens L (Dec 2002). "Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)". Human Genetics. 111 (6): 544–7.
doi:
10.1007/s00439-002-0820-5.
PMID12436245.
S2CID28089635.
Wells RG, Pajor AM, Kanai Y, Turk E, Wright EM, Hediger MA (Sep 1992). "Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter". The American Journal of Physiology. 263 (3 Pt 2): F459-65.
doi:
10.1152/ajprenal.1992.263.3.F459.
PMID1415574.