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Chemical compound
Thiamylal
Other names Thiamylal, Thioseconal, Surital
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International Drug Names
ATCvet code
Legal status
Metabolism Hepatic
Elimination half-life 14.3 h (cats)
5-(Pentan-2-yl)-5-(prop-2-en-1-yl)-2-sulfanylidenedihydropyrimidine-4,6(1H ,5H )-dione
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ECHA InfoCard
100.000.927
Formula C 12 H 18 N 2 O 2 S
Molar mass 254.35 g·mol−1 3D model (
JSmol )
O=C1NC(=S)NC(=O)C1(C(C)CCC)C\C=C
InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17)
Y Key:XLOMZPUITCYLMJ-UHFFFAOYSA-N
Y
(verify)
Thiamylal (Surital ) is a
barbiturate derivative invented in the 1950s. It has
sedative ,
anticonvulsant , and
hypnotic effects, and is used as a strong but short acting sedative. Thiamylal is still in current use, primarily for induction in
surgical
anaesthesia
[2] or as an anticonvulsant to counteract side effects from other anaesthetics.
[3] It is the thiobarbiturate analogue of
secobarbital .
References
^
Anvisa (2023-03-31).
"RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).
Diário Oficial da União (published 2023-04-04).
Archived from the original on 2023-08-03. Retrieved 2023-08-16 .
^ Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B (2005). "Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia". Acta Paediatrica Taiwanica = Taiwan Er Ke Yi Xue Hui Za Zhi . 46 (5): 294–300.
PMID
16640004 .
^ Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV (February 2007).
"Seizure after local anesthesia for nasopharyngeal angiofibroma" . The Kaohsiung Journal of Medical Sciences . 23 (2): 97–100.
doi :
10.1016/S1607-551X(09)70383-3 .
PMID
17339174 .
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