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Chemical compound
Dimdazenil (trade name Junoenil ) is a pharmaceutical drug for
insomnia .
[1] It is a
benzodiazepine
derivative and a partial
positive allosteric modulator of the GABAA receptor
[2] with two- to four-fold higher functional
affinity for the
α1 subunit relative to the
α2 ,
α3 , and
α5 subunits .
Medical use
Dimdezenil shows effectiveness in the treatment of
insomnia , but has less
intrinsic activity in comparison to currently-marketed benzodiazepines and the
Z-drugs ;
[3] however, it is thought that the lower efficacy may result in fewer
side effects , such as
motor incoordination .
[3] In China, dimdezenil is approved for short-term treatment of insomnia.
[4]
History
Dimdezenil was originally developed by
Roche , based on
preclinical data, as a non-
sedating
anxiolytic , but was found to produce
sedation in humans in
phase I
clinical trials . For this reason, it was subsequently licensed to
Evotec , which is now developing it for the treatment of insomnia.
[3] By 2007, dimdezenil completed
phase II clinical trials for this indication, with positive findings reported.
[5] In China, the drug was developed by Zhejiang Jingxin Pharmaceutical.
References
^ Huang Z, Zhan S, Chen C, Zhang R, Zhou Y, He J, et al. (February 2024).
"Efficacy and safety of Dimdazenil in adults with insomnia disorder: results from a multicenter, randomized, double-blind, placebo-controlled phase III trials" . Sleep . 47 (2).
doi :
10.1093/sleep/zsad272 .
PMC
10851846 .
PMID
37875349 .
^ Guilleminault C (2010).
Sleep Medicine . Elsevier Health Sciences. pp. 574–.
ISBN
978-1-4377-1836-2 .
^
a
b
c Monti JM, Pandi-Perumal SR, Möhler H (28 September 2010).
GABA and Sleep: Molecular, Functional and Clinical Aspects . Springer Science & Business Media. pp. 50–51.
ISBN
978-3-0346-0226-6 .
^ Syed YY (March 2024).
"Dimdazenil: First Approval" . Drugs .
doi :
10.1007/s40265-024-02020-9 .
PMID
38546956 .
^ Plunkett JW (September 2007).
Plunkett's Biotech & Genetics Industry Almanac 2008: Biotech & Genetics Industry Market Research, Statistics, Trends & Leading Companies . Plunkett Research, Ltd. pp. 311–.
ISBN
978-1-59392-087-6 .
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