Common side effects are headache, confusion, fast heartbeat, and
edema. Hypersensitivity reactions are rare and include
angioedema.[3]
Interactions
The substance is metabolized by the liver enzyme
CYP3A4. Consequently, CYP3A4 inducers such as
rifampicin or
carbamazepine could reduce the effectiveness of nisoldipine, while CYP3A4 inhibitors such as
ketoconazole increase the amount of nisoldipine in the body more than 20-fold.
Grapefruit juice also increases nisoldipine concentrations by inhibiting CYP3A4.[3]
^Knorr AM (April 1995). "Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?". The American Journal of Cardiology. 75 (13): 36E–40E.
doi:
10.1016/S0002-9149(99)80446-9.
PMID7726122.
Mielcarek J, Grobelny P, Szamburska O (April 2005). "The effect of beta-carotene on the photostability of nisoldipine". Methods and Findings in Experimental and Clinical Pharmacology. 27 (3): 167–171.
doi:
10.1358/mf.2005.27.3.890873.
PMID15834448.
Hamilton SF, Houle LM, Thadani U (1999). "Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure". Heart Disease. 1 (5): 279–288.
PMID11720635.