Ethinamate (1-ethynylcyclohexanone carbamate) is synthesized by combining
acetylene with
cyclohexanone to make
1-ethynylcyclohexanol, and then transforming this into a
carbamate by the subsequent reaction with
phosgene, and later with
ammonia. Some lithium metal or similar is used to make the acetylene react with the cyclohexanone in the first step.[3][4]
^Lowry WT, Garriot JC (1979).
"Ethinamate". Forensic Toxicology: Controlled Substances and Dangerous Drugs. Boston, MA: Springer US. p. 215.
ISBN978-1-4684-3444-6.
^US 2816910, Pfeiffer H, Junkman K, "Esters of carbamic acid and a method of making same", issued 17 December 1957, assigned to Schering AG
^DE 1021843, Emde H, Grimme W, "Verfahren zur Herstellung des Allophanats des 1-AEthinylcyclohexanols-(1)", issued 2 January 1958, assigned to Rheinpreussen AG