From Wikipedia, the free encyclopedia
Combination drug
Tetrabamate (Atrium , G Tril , Sevrium ) is a
combination drug
formulation of
febarbamate ,
difebarbamate , and
phenobarbital which was marketed in
France and
Spain and was used to treat
anxiety and
alcohol withdrawal -associated
muscle tremors ,
agitation , and
depression .
[1]
[2]
[3]
[4] It was largely, but not completely
discontinued on April 4, 1997, after over 30 years of use due to reports of
hepatitis and
acute liver failure .
[3]
[4]
[5]
[6] The decision to restrict the use of the drug had been long-awaited.[
clarification needed ]
[6]
References
^
Index nominum 2000: international drug directory . Taylor & Francis US. 2000. pp. 333 & 427.
ISBN
978-3-88763-075-1 . Retrieved 26 November 2011 .
^ Chitturi S, Farrell GC (19 October 2011).
"Drug-Induced Liver Disease" . In Schiff ER, Maddrey WC, Sorrell MF (eds.). Schiff's Diseases of the Liver . John Wiley and Sons. pp. 703–783.
doi :
10.1002/9781119950509.ch27 .
ISBN
978-1-119-95048-6 . Retrieved 26 November 2011 .
^
a
b Binder D, Jost R, Flury R, Salomon F (May 1995). "[Acute liver failure following tetrabamate]". Schweizerische Medizinische Wochenschrift (in German). 125 (19): 965–969.
PMID
7761807 .
^
a
b
Consolidated list of products whose consumption and/or sale have been banned, withdrawn, severely restricted or not approved by governments . United Nations Publications. 2003. p. 259.
ISBN
978-92-1-130230-1 . Retrieved 26 November 2011 . [
permanent dead link ]
^ Horsmans Y, Lannes D, Pessayre D, Larrey D (December 1994). "Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate". Journal of Hepatology . 21 (6): 1075–1079.
doi :
10.1016/s0168-8278(05)80620-8 .
PMID
7699230 .
^
a
b "Severe hepatitis due to Atrium". Prescrire International . 10 (55): 150. October 2001.
PMID
11824432 .
Alcohols
Barbiturates
Benzodiazepines
Carbamates
Flavonoids
Imidazoles
Kava constituents
Monoureides
Neuroactive steroids
Nonbenzodiazepines
Phenols
Piperidinediones
Pyrazolopyridines
Quinazolinones
Volatiles /
gases Others/unsorted
3-Hydroxybutanal
α-EMTBL
AA-29504
Alogabat
Avermectins (e.g.,
ivermectin )
Bromide compounds (e.g.,
lithium bromide ,
potassium bromide ,
sodium bromide )
Carbamazepine
Chloralose
Chlormezanone
Clomethiazole
Darigabat
DEABL
Deuterated etifoxine
Dihydroergolines (e.g.,
dihydroergocryptine ,
dihydroergosine ,
dihydroergotamine ,
ergoloid (dihydroergotoxine) )
DS2
Efavirenz
Etazepine
Etifoxine
Fenamates (e.g.,
flufenamic acid ,
mefenamic acid ,
niflumic acid ,
tolfenamic acid )
Fluoxetine
Flupirtine
Hopantenic acid
KRM-II-81
Lanthanum
Lavender oil
Lignans (e.g.,
4-O-methylhonokiol ,
honokiol ,
magnolol ,
obovatol )
Loreclezole
Menthyl isovalerate (validolum)
Monastrol
Niacin
Niacinamide
Org 25,435
Phenytoin
Propanidid
Retigabine (ezogabine)
Safranal
Seproxetine
Stiripentol
Sulfonylalkanes (e.g.,
sulfonmethane (sulfonal) ,
tetronal ,
trional )
Terpenoids (e.g.,
borneol )
Topiramate
Valerian constituents (e.g.,
isovaleric acid ,
isovaleramide ,
valerenic acid ,
valerenol )