Piberaline (EGYT-475; Trelibet) is a
psychoactive drug and member of the
piperazinechemical class which was
developed in the 1980s. It has
stimulant and
antidepressant effects which are thought to be due largely to its active metabolite
benzylpiperazine.[1] It was researched to a limited extent in Hungary and Spain, but was not widely accepted and does not seem to be in current use, although a closely related drug
befuraline with similar effects has been slightly more successful.
^Tekes K, Tóthfalusi L, Malomvölgyi B, Hermán F, Magyar K (1987). "Studies on the biochemical mode of action of EGYT-475, a new antidepressant". Polish Journal of Pharmacology and Pharmacy. 39 (2): 203–11.
PMID2448760.
^Jenoe Dr. Koroesi, 5 More », DE 2215545 (1975 to Egyt Gyogyszervegyeszeti Gyar, Budapest).
^Kumar, Kamal; Michalik, Dirk; Garcia Castro, Ivette; Tillack, Annegret; Zapf, Alexander; Arlt, Michael; Heinrich, Timo; Böttcher, Henning; Beller, Matthias (2004). "Biologically Active Compounds through Catalysis: Efficient Synthesis ofN-(Heteroarylcarbonyl)-N′-(arylalkyl) piperazines". Chemistry - A European Journal. 10 (3): 746–757. doi:10.1002/chem.200305327.
^Younes, S (2000). "Synthesis and structure–activity relationships of novel arylalkyl 4-benzyl piperazine derivatives as σ site selective ligands". European Journal of Medicinal Chemistry. 35 (1): 107–121. doi:10.1016/S0223-5234(00)00113-6.