From Wikipedia, the free encyclopedia
Chemical compound
Pyrovalerone (Centroton , 4-Methyl-β-keto-prolintane , Thymergix , O-2371 )
[2] is a
psychoactive drug with
stimulant
effects via
acting as a
norepinephrine-dopamine reuptake inhibitor (NDRI). It was
developed in the 1980s and had briefly been approved in Spain and France for
chronic fatigue or
lethargy
[3] and as an
anorectic or
appetite suppressant , but was withdrawn from both markets around 2001 due to safety concerns including problems with
abuse and
dependence .
[4] It is closely related on a
structural level to a number of other cathinone stimulants, such as
α-PVP ,
MDPV and
prolintane (Promotil, Katovit).
Side effects of pyrovalerone include
anorexia or
loss of appetite ,
anxiety , fragmented
sleep or
insomnia , and
trembling ,
shaking , or
muscle tremors .
Withdrawal following abuse upon discontinuation often results in
depression .
The R -
enantiomer of pyrovalerone is devoid of pharmacologic activity.
[5]
See also
References
^
Anvisa (2023-03-31).
"RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).
Diário Oficial da União (published 2023-04-04).
Archived from the original on 2023-08-03. Retrieved 2023-08-16 .
^ US Patent 3314970
^ Gardos G, Cole JO (October 1971). "Evaluation of pyrovalerone in chronically fatigued volunteers". Current Therapeutic Research, Clinical and Experimental . 13 (10): 631–5.
PMID
4402508 .
^ Deniker P, Lôo H, Cuche H, Roux JM (November 1975). "[Abuse of pyrovalerone by drug addicts]". Annales médico-psychologiques . 2 (4): 745–8.
PMID
9895 .
^ Meltzer PC, Butler D, Deschamps JR, Madras BK (February 2006).
"1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors" . Journal of Medicinal Chemistry . 49 (4): 1420–32.
doi :
10.1021/jm050797a .
PMC
2602954 .
PMID
16480278 .
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