para-Chloroamphetamine has been detected as an apparent
designer drug,[6] along with the related
3-chloroamphetamine, which is even more potent as a releaser of dopamine and serotonin but slightly less neurotoxic.[7][8][9][10][11]
The closely related N-methylated derivative,
para-chloromethamphetamine (CMA), which is metabolized to para-chloroamphetamine in vivo, has neurotoxic properties as well.
Legal status
China
As of October 2015, 4-CA is a controlled substance in China.[12]
^Fuller RW, Schaffer RJ, Roush BW, Molloy BB (May 1972). "Drug disposition as a factor in the lowering of brain serotonin by chloroamphetamines in the rat". Biochemical Pharmacology. 21 (10): 1413–1417.
doi:
10.1016/0006-2952(72)90365-6.
PMID5029422.
^Ogren SO, Ross SB (October 1977). "Substituted amphetamine derivatives. II. Behavioural effects in mice related to monoaminergic neurones". Acta Pharmacologica et Toxicologica. 41 (4): 353–368.
doi:
10.1111/j.1600-0773.1977.tb02674.x.
PMID303437.
^Ross SB, Kelder D (May 1979). "Inhibition of 3H-dopamine accumulation in reserpinized and normal rat striatum". Acta Pharmacologica et Toxicologica. 44 (5): 329–335.
doi:
10.1111/j.1600-0773.1979.tb02339.x.
PMID474143.
^Fuller RW, Baker JC (November 1974). "Long-lasting reduction of brain 5-hydroxytryptamine concentration by 3-chloramphetamine and 4-chloroamphetamine in iprindole-treated rats". The Journal of Pharmacy and Pharmacology. 26 (11): 912–914.
doi:
10.1111/j.2042-7158.1974.tb09206.x.
PMID4156568.
S2CID41833796.
^Ross SB, Ogren SO, Renyi AL (October 1977). "Substituted amphetamine derivatives. I. Effect on uptake and release of biogenic monoamines and on monoamine oxidase in the mouse brain". Acta Pharmacologica et Toxicologica. 41 (4): 337–352.
doi:
10.1111/j.1600-0773.1977.tb02673.x.
PMID579062.
^"关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from
the original on 1 October 2015. Retrieved 1 October 2015.