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Opioid designer drug
AP-238
Legal status
1-[(2R,6S)-2,6-dimethyl-4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propan-1-one
CAS Number
PubChem
CID
ChemSpider
UNII
Formula C 18 H 26 N 2 O
Molar mass 286.419 g·mol−1 3D model (
JSmol )
CCC(=O)N1[C@@H](CN(C[C@@H]1C)C/C=C/C2=CC=CC=C2)C
InChI=1S/C18H26N2O/c1-4-18(21)20-15(2)13-19(14-16(20)3)12-8-11-17-9-6-5-7-10-17/h5-11,15-16H,4,12-14H2,1-3H3/b11-8+/t15-,16+
Key:JELNWDOXWGBBLO-QJBCGIKSSA-N
AP-238 is an
opioid
designer drug related to drugs such as
azaprocin and
bucinnazine , with around the same potency as
morphine .
[2] It was first discovered in Italy in the 1960s but was never marketed,
[3] subsequently appearing on the illicit market around 2020 and being detected in both Slovenia and the USA.
[4]
[5]
See also
References
^
"2-Methyl-AP-237" (PDF) . Office of Diversion Control . U.S Drug Enforcement Administration.
^ Fogarty MF, Vandeputte MM, Krotulski AJ, Papsun D, Walton SE, Stove CP, Logan BK (June 2022).
"Toxicological and pharmacological characterization of novel cinnamylpiperazine synthetic opioids in humans and in vitro including 2-methyl AP-237 and AP-238" . Archives of Toxicology . 96 (6): 1701–1710.
doi :
10.1007/s00204-022-03257-7 .
PMID
35275255 .
S2CID
247383361 .
^ Cignarella G, Testa E (May 1968). "2,6-Dialkylpiperazines. IV. 1-Propionyl-4-substituted cis-2,6-dimethylpiperazines structurally related to the analgetic 8-acyl-3,8-diazabicyclo[3.2.1]octanes". Journal of Medicinal Chemistry . 11 (3): 592–594.
doi :
10.1021/jm00309a039 .
PMID
5656502 .
^ {{cite web | url =
https://www.policija.si/apps/nfl_response_web/0_Analytical_Reports_final/AP-238-ID-2185-20_report.pdf | title = Analytical Report. AP-238. 1-{2,6‐dimethyl‐4‐[(2E)‐3‐phenylprop‐2‐en‐1‐yl]piperazin‐1‐yl}propan-1-one. | work =Nacionalni Forenzični Laboratorij | date = 20 October 2020 }}
^
"AP-238" (PDF) . NPS Discovery at CFSRE . Center for Forensic Science Research and Education (CFSRE). 11 November 2020.
Simple piperazines(no additional rings)
Phenylpiperazines
2C-B-PP
3,4-CFP
Acaprazine
Antrafenine
Aripiprazole
Batoprazine
Bifeprunox
BRL-15,572
Ciprofloxacin
CSP-2503
Dapiprazole
DCPP
DMPP
Diphenylpiperazine
Dropropizine
EGIS-12,233
Elopiprazole
Eltoprazine
Enpiprazole
Ensaculin
Etoperidone
Flesinoxan
Fluanisone
Flibanserin
Fluprazine
Itraconazole
Ketoconazole
Levodropropizine
Lorpiprazole
mCPP
Mefway
MeOPP
Mepiprazole
Naftopidil
Naluzotan
Naphthylpiperazine
Nefazodone
Niaprazine
Oxypertine
Pardoprunox
pCPP
pFPP
Posaconazole
S-14,506
S-14,671
S-15,535
SB-258,585
SB-271,046
SB-357,134
SB-399,885
Sonepiprazole
TFMPP
Tolpiprazole
Trazodone
Urapidil
Vesnarinone
Vilazodone
Vortioxetine
WAY-100,135
WAY-100,635
Benzylpiperazines
Diphenylalkylpiperazines (benzhydrylalkylpiperazines)
Pyrimidinylpiperazines
Pyridinylpiperazines
Benzo(iso)thiazolyl
piperazines
Tricyclics (piperazine attached via side chain) Others/Uncategorized