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Triple reuptake inhibitor investigated by the Mayo Clinic
PRC200-SS is an experimental drug of the
triple reuptake inhibitor class that was investigated by the
Mayo Clinic .
[1]
[2]
Preclinical toxicology studies of PRC200-SS in
cynomolgus monkeys showed dose proportional kidney toxicity,
[3] precluding any further
drug development .
References
^ Liang Y, Shaw AM, Boules M, Briody S, Robinson J, Oliveros A, et al. (November 2008). "Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)". The Journal of Pharmacology and Experimental Therapeutics . 327 (2): 573–83.
doi :
10.1124/jpet.108.143610 .
PMID
18689611 .
S2CID
12635418 .
^
"Triple Reuptake Inhibitors for the Treatment of Depression" . Mayo Clinic Ventures.
^ Guha M, Heier A, Price S, Bielenstein M, Caccese RG, Heathcote DI, et al. (April 2011).
"Assessment of biomarkers of drug-induced kidney injury in cynomolgus monkeys treated with a triple reuptake inhibitor" . Toxicological Sciences . 120 (2): 269–83.
doi :
10.1093/toxsci/kfr013 .
PMID
21258088 .
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