From Wikipedia, the free encyclopedia
Chemical compound
Sonepiprazole (U-101,387, PNU-101,387-G) is a
drug of the
phenylpiperazine class which acts as a highly
selective
D4 receptor
antagonist.
[1] In animals, unlike
D2 receptor antagonists like
haloperidol, sonepiprazole does not block the behavioral effects of
amphetamine or
apomorphine, does not alter spontaneous
locomotor activity on its own, and lacks
extrapyramidal and
neuroendocrine effects.
[2] However, it does reverse the
prepulse inhibition deficits induced by apomorphine,
[3] and has also been shown to enhance
cortical activity and inhibit
stress-induced
cognitive impairment.
[4]
[5] As a result, it was investigated as an
antipsychotic for the treatment of
schizophrenia in a
placebo-controlled
clinical trial, but in contrast to its comparator
olanzapine no benefits were found and it was not researched further for this indication.
[6]
[7]
See also
References
-
^ TenBrink RE, Bergh CL, Duncan JN, et al. (June 1996). "(S)-(−)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist". Journal of Medicinal Chemistry. 39 (13): 2435–7.
doi:
10.1021/jm960084f.
PMID
8691438.
-
^ Merchant KM, Gill GS, Harris DW, et al. (December 1996).
"Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist". The Journal of Pharmacology and Experimental Therapeutics. 279 (3): 1392–403.
PMID
8968364.
-
^ Mansbach RS, Brooks EW, Sanner MA, Zorn SH (January 1998).
"Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition". Psychopharmacology. 135 (2): 194–200.
doi:
10.1007/s002130050501.
PMID
9497025.
S2CID
9246828.
-
^ Rubinstein M, Cepeda C, Hurst RS, et al. (June 2001).
"Dopamine D4 receptor-deficient mice display cortical hyperexcitability". Journal of Neuroscience. 21 (11): 3756–63.
doi:
10.1523/JNEUROSCI.21-11-03756.2001.
hdl:
11336/79333.
PMC
6762699.
PMID
11356863.
-
^ Arnsten AF, Murphy B, Merchant K (October 2000).
"The selective dopamine D4 receptor antagonist, PNU-101387G, prevents stress-induced cognitive deficits in monkeys". Neuropsychopharmacology. 23 (4): 405–10.
doi:
10.1016/S0893-133X(00)00133-0.
PMID
10989267.
-
^ Unangst PC, Capiris T, Connor DT, et al. (August 1997). "Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents". Journal of Medicinal Chemistry. 40 (17): 2688–93.
doi:
10.1021/jm970170v.
PMID
9276014.
-
^ Corrigan MH, Gallen CC, Bonura ML, Merchant KM (March 2004). "Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial". Biological Psychiatry. 55 (5): 445–51.
doi:
10.1016/j.biopsych.2003.10.004.
PMID
15023570.
S2CID
108634.
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Simple piperazines (no additional rings) | |
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Phenylpiperazines |
-
2C-B-PP
-
3,4-CFP
-
Acaprazine
-
Antrafenine
-
Aripiprazole
-
Batoprazine
-
Bifeprunox
-
BRL-15,572
-
Ciprofloxacin
-
CSP-2503
-
Dapiprazole
-
DCPP
-
DMPP
-
Diphenylpiperazine
-
Dropropizine
-
EGIS-12,233
-
Elopiprazole
-
Eltoprazine
-
Enpiprazole
-
Ensaculin
-
Etoperidone
-
Flesinoxan
-
Fluanisone
-
Flibanserin
-
Fluprazine
-
Itraconazole
-
Ketoconazole
-
Levodropropizine
-
Lorpiprazole
-
mCPP
-
Mefway
-
MeOPP
-
Mepiprazole
-
Naftopidil
-
Naluzotan
-
Naphthylpiperazine
-
Nefazodone
-
Niaprazine
-
Oxypertine
-
Pardoprunox
-
pCPP
-
pFPP
-
Posaconazole
-
S-14,506
-
S-14,671
-
S-15,535
-
SB-258,585
-
SB-271,046
-
SB-357,134
-
SB-399,885
-
Sonepiprazole
-
TFMPP
-
Tolpiprazole
-
Trazodone
-
Urapidil
-
Vesnarinone
-
Vilazodone
-
Vortioxetine
-
WAY-100,135
-
WAY-100,635
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Benzylpiperazines | |
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Diphenylalkylpiperazines (benzhydrylalkylpiperazines) | |
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Pyrimidinylpiperazines | |
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Pyridinylpiperazines | |
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Benzo(iso)thiazolyl
piperazines | |
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Tricyclics (piperazine attached via side chain) | |
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Others/Uncategorized | |
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