Diphenpipenol is an
opioidanalgesic drug invented in the 1970s by
Dainippon Pharmaceutical Co.[1] It is chemically a 1-substituted-4-(1,2-diphenylethyl)
piperazine derivative related to compounds such as
MT-45 and
AD-1211, but diphenpipenol is the most potent compound in the series, with the more active (S) enantiomer being around 105 times the potency of
morphine in animal studies.[2] This makes it a similar strength to
fentanyl and its analogues, and consequently diphenpipenol can be expected to pose a significant risk of producing life-threatening
respiratory depression, as well as other typical opioid side effects such as
sedation,
itching,
nausea and
vomiting.
Diphenpipenol has been offered for sale online as a
designer drug, though analysis of a sample of supposed diphenpipenol found it to instead contain a structural isomer with much weaker opioid activity, and it is unclear if genuine diphenpipenol has actually been sold.[3]
^US 4080453, Nishimura H, Uno H, Natsuka, Shimokawa N, Shimizu M, Nakamura H, "1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and compositions containing the same.", issued 21 March 1978, assigned to Dainippon Pharmaceutical Co Ltd
^Natsuka K, Nakamura H, Nishikawa Y, Negoro T, Uno H, Nishimura H (October 1987). "Synthesis and structure-activity relationships of 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives having narcotic agonist and antagonist activity". Journal of Medicinal Chemistry. 30 (10): 1779–87.
doi:
10.1021/jm00393a017.
PMID3656354.
^Cannaert A, Hulpia F, Risseeuw M, Van Uytfanghe K, Deconinck E, Van Calenbergh S, et al. (June 2020). "Report on a new opioid NPS: chemical and in vitro functional characterization of a structural isomer of the MT-45 derivative diphenpipenol". Journal of Analytical Toxicology. 45 (2): 134–140.
doi:
10.1093/jat/bkaa066.
hdl:1854/LU-8664239.
PMID32514558.